Vaccines for gas infections, Biology

Assignment Help:

In developing countries because of poor compliance, poverty, ignorance, primary and secondary prevention strategies are difficult to implement properly. Also in western countries (USA), where there is resurgence of ARF, interest in vaccine development has appeared. However, there are quite a few technical problems in development of vaccines. There are 2 types of vaccines.

I) Vaccines Against Virulence Factors Conserved Amongst Various GAS Despite antibodies to these conserved antigens, people are affected by multiple serotypes of GAS. Hence there remains a doubt regarding the protective efficacy of antibodies against GAS infections.

II) Vaccines Based on Type Specific, Hypervariable N-terminal Regions of M Proteins Life long immunity which is protective (25 to 30 years after infection) is achieved by antibodies against the hypervariable N-terminal of M-Protein. Considering this fact, using recombinant DNA technology, synthetic peptide copies of the hypervariable N-terminal of the M-protein are being manufactured. These synthetic peptides produce only bacterial antibodies without host cross-reactive antibodies. Currently N-terminal synthetic peptides of multiple serotypes of GAS are linked to a carrier protein to produce opsonizing antibodies. Tetra, hexa and octavalent vaccines incorporating M 1, 2, 3, 5, 6, 18, 19 and 24 N-terminal peptides are being evaluated in animals.


Related Discussions:- Vaccines for gas infections

Define the management of epileptic patients, Define the Management of Epile...

Define the Management of Epileptic Patients? The primary treatment of epilepsy is anticonvulsant drugs. The focus of nutritional management is a diet, which is appropriate for

Pulmonary ventilation, Pulmonary Ventilation: Pulmonary ventilation is th...

Pulmonary Ventilation: Pulmonary ventilation is the process by which gasses flow between the atmosphere and lung alveoli. Air moves into the  lungs when air pressure  inside the

Explain treatment options for ailing and failing implants, Treatment option...

Treatment options for ailing and failing implants are varied. The clinician should start conservatively and progress to more aggressive therapy. The overall goal of therapy is

Mycotoxicoses, Mycotoxicoses Mycotoxicoses cause heavy economic loss d...

Mycotoxicoses Mycotoxicoses cause heavy economic loss due to high morbidity and consequent production loss. Low grade mortality is also recorded. The main toxins involved are

Right coronary artery, Right coronary artery arises from the anterior aorti...

Right coronary artery arises from the anterior aortic sinus. It runs down along the anterior part of the coronary sulcus, reaches the lower border of heart turns round the lower bo

What is the objectives of evaluation of patient clinical, What is the OBJEC...

What is the OBJECTIVES of evaluation of patient clinical examination ? After going through this unit, you should be able to: 1. Carried out the general physics-examination; 2.

What are the types of neurons, According to the function of the transmitted...

According to the function of the transmitted neural impulse which are the types of neurons? How different are the concepts of afference and efference of the neural impulse transmis

Define the carbohydrate utilization pattern test, Define the Carbohydrate U...

Define the Carbohydrate Utilization Pattern Test? Carbohydrates are composed of carbon, hydrogen and oxygen. These organic molecules are catabolized by large number of microorg

Define isomerases, Isomerases These  enzymes (code  EC 5)  catalyze geo...

Isomerases These  enzymes (code  EC 5)  catalyze geometric  or  structural  changes  within  a molecule. According  to the  type of  isomerism,  they  may be  called  racemases

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd