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a) The West of Scotland Coronary Prevention Study (WOSCOPS): The study randomized healthy men between the ages of 45 and 64 years with TC levels higher that 252 mg/dL and LDL cholesterol levels of 174 to 232 mg/dL to pravastatin (40mg/day) or to placebo for an average of 5 years and demonstrated a 31 per cent relative reduction in the incidence of nonfatal MI or CAD death.
b) The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS): AFCAPS/TexCAPS capitalized on the increased risk among healthy persons with low HDL levels (mean, 36mg/dL) and high TC levels (mean, 221 mg/dL). Therapy with the cholesterol-lowering drug lovastatin reduced by 36 per cent the risk for first acute major coronary events among healthy adults with average to mildly elevated cholesterol levels and low HDL levels.
c) The Heart Protection Study (HPS) (5) randomized 20,536 subjects to daily simvastatin (40mg) or placebo and to antioxidants or placebo (the antioxidant arm did not show any benefit or harm). The study focused on patients who were deemed high risk but not thought to merit treatment with statins based on the prevalent clinical practice. Increased risk was defined as presence of or history of Coronary Artery Disease, cerebovascular disease, peripheral vascular disease, diabetes mellitus, or treated hypertension in men younger than 65 years. Simvastatin therapy was associated with a 17 per cent relative reduction in the risk of death, driven primarily by a 17 per cent relative risk reduction in nonfatal MI, a 25 per cent relative reduction in the incidence of first stroke, 30 per cent reduction in coronary revascularisation, and 16 per cent reduction in noncoronary revascularization procedures were observed. Event reduction was similar across multiple subgroups and was largely uninfluenced by pretreatment lipoprotein values. Treating LDL levels less than 100mg/dL was also associated with a beneficial reduction in vascular events.
#in which part of alimentary canal oblique muscle found?
Nursing Process Assessment History, precipitating factors, current medication, medication used to relieve asthma symptoms. Any recent changes in medication regimen.
what term is used to indicate its grooves?
Q. Illustrate Stents? Stents are metallic scaffolds that are deployed within a diseased segment of a coronary artery to establish and then maintain a widely patent lumen. Stent
what type of skull does amphibians possess in general?
Evolution can be explained as follows 1) The change in the life over time by adaptation, over-reproduction, variation and differential survival/reproduction, a procedure refer
what''s the role of lungs in terms of excretion? Like the trachea what''s its role in excretory system?
Amphibian frog embryo
Describe MS Murmur in Diastolic Murmurs briefly? Characteristic: Low pitched, rumbling and diastolic murmur, loudest at apex with patient in left lateral decubitus, with pre
discovery of two light phase in photosynthesis
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