Explain the Multiple Organ Dysfunction Syndrome (MODS)

Failure of essential organs is the most severe complication of sepsis and may result in death. The treatment of systemic infection, therefore, consists of use of antibiotics, support of cardiovascular and respiratory function, supportive therapy of specific organs and vigorous nutrition support. Septic shock may lead to a decrease in peripheral resistance and cause pulmonary insufficiency. Patients often require ventilator support. Inadequate cardiac output may lead to impairment and malfunction of the kidney.

The resulting uremia superimposed on the sepsis further impairs the hyper catabolic infected host. Sepsis causes marked changes in the structure/ function of gastrointestinal tract and may lead to stress ulcers and bleeding. Septicemia also commonly leads to hepatic dysfunction causing jaundice, hyperbilirubinemia and liver failure. Multi-system organ failure or MODS is associated with a high incidence of death.