Reference no: EM133879650

Question 

Revise in simple english: Osteoarthritis (OA), also called osteoarthrosis, is the most common progressive chronic joint disease among older people. It leads to significant, chronic pain, the loss of mobility, and disability [1]. Osteoarthritis affects most people over the age of 65 [2]. An increasing trend in the number of people suffering from osteoarthritis has been observed around the world. An estimated 7% of the global population is affected by OA [3]. In 2019, there were over 500 million people with the disease [4]. The prevalence of OA is one in five among the general population and one in three among those over the age of 50 [3,5,6]. There are a variety of synovial joints that can develop OA, but the hands, knees, and hips are the most commonly affected [7]. There is an estimated 16% of the world's population diagnosed with knee OA, with women suffering from the condition at a higher rate [6]. In the past, osteoarthritis was thought to be solely the result of cartilage "wear and tear". Currently, it is understood as a complex, joint-wide condition involving matrix proteases and affecting the entire joint.