Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Determine the groups of soil organisms, Determine the groups of soil organi...

Determine the groups of soil organisms The soil organisms are classified into two broad groups viz. soil flora (related to plants) and soil fauna (related to animals) which ar

What does a two-direction arrow show in a chemical equation, What does a tw...

What does a two-direction arrow show in a chemical equation? The oxygen atoms share two pairs of electrons, as every atom needs two more electrons to fill the orbitals of its o

Main factors for the growth of a population, Q. What are the main limiting ...

Q. What are the main limiting factors for the growth of a population? The factors that bound the growth of a population can be divided into abiotic factors and biotic factors.

Complications of diabetes, Q. Complications of Diabetes? Diabetes, as y...

Q. Complications of Diabetes? Diabetes, as you know, is a lifelong disease. We have said earlier also that it can be controlled but not cured. Control of diabetes by ensuring n

What is black mold, What is black mold? Mold is a fungus. Black mold is...

What is black mold? Mold is a fungus. Black mold is not an official term, since it is not possible to tell with the naked eye what type of mold is present, and many of them app

What is the notochord, What is the notochord? How is this structure formed?...

What is the notochord? How is this structure formed? The notochord is a rodlike structure that produces the supporting axis of the embryo and gives birth to the vertebral colum

Explain exposure assessment, Exposure  assessment Estimates of dietary...

Exposure  assessment Estimates of dietary intakes of food additives, residues of pesticides and veterinary drugs and contaminants require information on the consumption of rele

Define micronutrients requirements for anorexia nervosa, Define Micronutrie...

Define Micronutrients Requirements for Anorexia Nervosa? It is advisable to include one 100% RDA multivitamin tablet with minerals. The use of prophylactic thiamine supplements

What is the requirements of dental implants, Requirements of Dental implant...

Requirements of Dental implants Dental implants require special oral hygiene techniques. The particular technique chosen often depends upon the prosthesis.  A removable prosth

What is carbon cycle explain briefly, What is Carbon Cycle explain briefly?...

What is Carbon Cycle explain briefly? Life on earth is mainly carbon-based. Most of the material substances that make up living organisms consist of organic compounds of carbon

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd