Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

State the bio-medical waste management, Bio-medical waste management Pe...

Bio-medical waste management Persons coming in contact with bio-medical waste are prone to get injury from sharps likes needles. Injury due to sharps leads to life threatening

Classification of carbohydrates - degree of polymerization, Define Classifi...

Define Classification of Carbohydrates - Degree of Polymerization? Classification on the basis of Degree of Polymerization (DP) Carbohydrates are classified by their degree

Eye muscles, MUSCLES - In eye orbit, eye ball is fixed by 6 skeletal...

MUSCLES - In eye orbit, eye ball is fixed by 6 skeletal muscles attached to 3rd, 4th & 6th cranial nerves (motor). 4 - straight or recti muscles are present. 2 - oblique

Can you explain cholera, Q. Can you explain Cholera? Cholera is one of ...

Q. Can you explain Cholera? Cholera is one of the diseases which had caused epidemics all over the world. The organism which causes the disease is Vibrio cholerae. It is an

Define food quality factors and their measurement, Define Food quality fact...

Define Food quality factors and their measurement? Appearance; textural, flavour, nutritional, sanitary and keeping factors; quality standards, objective and organoleptic evalu

What are the classification of reasons of implant failure, Classification o...

Classification of the reasons of implant failure: In order to understand failures it is vital to know, why they occur. The reasons are plenty and to streamline, these have been

Effect of temperature, Effect of Temperature Certain plants such as th...

Effect of Temperature Certain plants such as the winter rye (Secale cereale) and the biennial strain of henbane (Hyoscyamus Niger) require exposure to low temperature conditio

Explain the reinforcement of patch using fibrin glue, Explain the Reinforce...

Explain the Reinforcement of Patch using Fibrin Glue? Reinforcement of Patch using Fibrin Glue :  In this technique Dacron graft is first sutured to the septum beyond i

Trihybrid cross between two true-breeding homozygous, Which of the followin...

Which of the following statements is true regarding a trihybrid cross between two true-breeding homozygous individuals with contrasting phenotypes? Which of the following statement

Define japanese criteria for functional foods, Define Japanese criteria for...

Define Japanese criteria for functional foods? The Japanese criteria for functional foods include: They are food (not capsules, pills/powder) on the basis of naturally o

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd