Polypeptide chains of hemoglobin, Biology

Assignment Help:

Q. In sickle cell anemia, a hereditary disease, there is replacement of one amino acid by another in one of the four polypeptide chains of hemoglobin. In this case are all of the structural levels of the protein modified?

In sickle cell disease there is a modification in the primary protein structure of one of the polypeptide chains that form haemoglobin, the amino acid glutamic acid is substituted by the amino acid valine in the β chain. The spatial conformation of the molecule in addition is also modified and affected by this primary "mistake" and the modification also creates a different (sickle) shape to the red blood cells.

Sickled, Modified, red blood cells sometimes aggregate and obstruct the peripheral circulation causing tissue hypoxia and the pain crisis typical of sickle cell anemia.


Related Discussions:- Polypeptide chains of hemoglobin

Phylum Protozoa, salient features of phylum Protozoa

salient features of phylum Protozoa

How many grams of sodium dodecyl sulfate need, How many grams of sodium dod...

How many grams of sodium dodecyl sulfate (mw = 288.37) would you dissolve in 80mLs of water to make a 20% solution of SDS?

Under which form is nitrogen fixed by living beings, Under which form is ni...

Under which form is nitrogen fixed by living beings? Most living beings cannot use molecular nitrogen to get nitrogen atoms. Producers fix nitrogen mostly from nitrate (NO3-).

Explain the importance of the auxin, a) How is the milk production regulate...

a) How is the milk production regulated by hormones in human female? Define. b) Explain the importance of the auxin / cytokinin ratio in plant tissue culture.

Indications for surgery, Indications for Surgery :  Patients with moderate...

Indications for Surgery :  Patients with moderate or severe tricuspid regurgitation that is functional will need tricuspid annuloplasty at the time of correction of mitral valve d

Explain deet, DEET DEET is available in the US in many formulations wi...

DEET DEET is available in the US in many formulations with concentrations of 5%-40% and 100%; higher concentrations present complete protection for a longer period of time, bu

What are the parts of nervous system, What are the parts of Nervous system ...

What are the parts of Nervous system Nervous system is divided into three main parts: 1) The brain and spinal cord or Central Nervous System (CNS). 2) The nerves or Peri

Final project, does this site just assist or does it take the exam for you

does this site just assist or does it take the exam for you

Can you explain tannins, Q. Can you explain Tannins? Tannins are anoth...

Q. Can you explain Tannins? Tannins are another class of compounds which interfere with the absorption of minerals like iron and reduce the availability of proteins by bindin

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd