Pathophysiology 

Leukocytes develop fiom stem cells located in the bone marrow. During  leukocyte maturation, cells become committed  to specific cell types and develop  through multiple stages  of differentiation  and along two distinct cell lines. Leukaemia occurs within  this maturation process. A  damaged  single cell is capable of indefinite  self-renewal, and produces poorly differentiated  blast cells. Leukaemic  blast cells have no functional purposes  and disrupt functioning  by replacing the normal bone marrow  element  and infiltrating various organs.