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Most proteins made by ribosomes on the RER (rough endoplasmic reticulum) are glycoproteins, which is they hold short chains of carbohydrates (oligosaccharides) covalently related to them during passage by the Golgi and RER complex. Two major types of oligosaccharide linkage exist:
? O-linked oligosaccharides are commonly attached to the protein through O-glycosidic bonds to OH groups of Thr or Ser side chains. The residues which are changed are frequently in a region of the polypeptide chain which is rich in Thr and Ser residues. In plant glycoproteins, the OH sets of hydroxyproline (Hyp) residues can be glycosylated, by the hydroxylysine (Hyl) reduce in the mammalian protein collagen can be O-glycosylated.
? N-linked oligosaccharides are related to the protein via N-glycosidic will bonds to the NH2 where the Asn occurs in the sequence Asn-X-Ser (or Thr) where X is many amino acids except Pro. If the Asn is N-glycosylated the Thr or Ser residue in this motif is not O-glycosylated.
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Fibroids, also called as leiomyomas, are benign smooth muscle tumors that happen in the uterus. They grow under the influence of estrogen and progesterone, and are therefore seen i
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The nucleus has an inner and an outer membrane and is perforated through 3000-4000 nuclear pores. Each pore having of a nuclear pore complex of more than 100 several proteins organ
Question 1 Is expression of cloned gene always a success? How does the method of molecular photo copying work? Question 2 Explain the control of gene expression with the exam
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