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Niacin affects all lipid parameters favorably. It is one of the only agents that reduces Lp (a) significantly (up to 30 per cent). Unfortunately, compliance is poor because of frequent side effects. Flushing and pruritus, gastrointestinal discomfort, glucose intolerance, and hyperuricemia often accompany use of niacin, hepatotoxicity is rare but is more commonly seen with the sustained released preparation. It is often heralded by a dramatic reduction in lipid levels. There are limited data on long-term therapy with this agent. Niacin may be particularly useful for patients who do not have substantial elevations in their LDL-C levels, and low doses may be used to treat diabetic dyslipidemia. High doses should be avoided in those with a history of gout, peptic ulcer disease, or active hepatic disease. Extended release preparations are to be used and not sustained release ones.
Explain Fomivirsen Fomivirsen, an antisense oligonu- cleotide, is FDA-approved for intravitreal treatment of CMV retinitis in HIV-infected patients who cannot tolerate or ha
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Q. Explain Clinical Manifestations of cardiomyopathy? 1) Asymptomatic, when the diagnosis is made by 2D Echocardiography. 2) Enlargement of LV. Apex is shifted down and out.
Is the transpiration the only way through which leaves lose water? The Plants don't only lose water as vapor as by transpiration. Leaves also lose liquid water by a phenomenon
Determine the Structure of Enzymes Since all enzymes are proteins, you will realize that knowledge of protein structure is clearly a pre-requisite to any understanding of enzym
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Signal Transduction The body consists of a huge variety of cell types which must work together to sustain the life of an organism. They must respond to their environment and co
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Several living organisms exhibit the unique property of producing visible light. Compound that is oxidized with subsequent light emission is generally referred to as luciferin. Wha
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