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Niacin affects all lipid parameters favorably. It is one of the only agents that reduces Lp (a) significantly (up to 30 per cent). Unfortunately, compliance is poor because of frequent side effects. Flushing and pruritus, gastrointestinal discomfort, glucose intolerance, and hyperuricemia often accompany use of niacin, hepatotoxicity is rare but is more commonly seen with the sustained released preparation. It is often heralded by a dramatic reduction in lipid levels. There are limited data on long-term therapy with this agent. Niacin may be particularly useful for patients who do not have substantial elevations in their LDL-C levels, and low doses may be used to treat diabetic dyslipidemia. High doses should be avoided in those with a history of gout, peptic ulcer disease, or active hepatic disease. Extended release preparations are to be used and not sustained release ones.
Trans Myocardial laser re vascularisation (TMLR) : Patients who have severe angina and diffuse coronary artery disease with no graftable vessels are at limes subjected to TMLR. I
Aortic Valve Replacement with Replacement of Aortic Root : When there is aneurysm of ascending aorta with aortic regurgitation, aortic root replacement is done. This
How is energy used to facilitate information transfer during transcription?
Define Regulation of intracellular Ca concentration? The cytoplasmic calcium concentration is regulated by a series of calcium pumps, which either concentrate calcium ions with
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Define Discovery of other Essential Nutrients? Following the identification of the food factors involved in beriberi, pellagra and scurvy, the search was on for other water-sol
Penicillin, discovered by the Scottish doctor Alexander Fleming, in 1928, is a drug that inhibits enzymes essential for the synthesis of peptidoglycans, a constituent of the bacter
Tolerance Model - Models of Succession In this model, the presence of early successional species is not essential, that is, any species can start succession. Some species are
Common Features of Eye and Limb Development A comparison of the embryonic development of the very much different organs, the eyes and the limb, points to various interesting
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