Explain polyenes - amphotericin b, Biology

Assignment Help:

Polyenes: amphotericin b

Amphotericin B products are the only polyenes currently available for systemic treatment of fungal infections.  Nystatin, another polyene, is only available topically.  A liposomal formulation of nystatin is in clinical development for treatment of systemic fungal infections containing invasive aspergillosis.

Polyenes act by binding to ergosterol in the fungal cell membrane, leading to loss of membrane integrity and leakage of cell contents. Conventional amphotericin B and the newer lipid-based formulations have the similar spectrum of activity and are active against most patho- genic fungi and some protozoa. Exceptions include Aspergillus ter- reus,  Fusarium spp.,  Pseudallescheria boydii and some strains of Candida lusitaniae. Amphotericin is used for treatment of many fungal disorders including aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis (containing meningitis), histoplasmosis, paracoccidioidomycosis, sporotrichosis and zygomycosis. It is also used as empiric therapy in febrile neutropenic patients.

 


Related Discussions:- Explain polyenes - amphotericin b

Why heartwood differs from sapwood, Heartwood differs from sapwood in: 1...

Heartwood differs from sapwood in: 1. Presence of rays and fibres 2. Absence of vessels and parenchyma 3. Having dead and non-conducting elements 4. Being susceptible t

Supply of animals in lab, Supply of Animals: Lab animals must be obtained ...

Supply of Animals: Lab animals must be obtained from accredited dealers and by accredited dealers, we mean suppliers in the business of supplying animals for lab use, and not from

Define resolution - terminologies used in chromatography, Define Resolution...

Define Resolution - terminologies used in chromatography? Resolution is the effectiveness of the separation and is determined by two factors. These include: Distance

#zoology, what is amniocentosis

what is amniocentosis

Cat scratch disease, Cat scratch disease It is caused by Bortenella he...

Cat scratch disease It is caused by Bortenella henselae, a gram-negative, non-motile bacterium. The organism is found in all parts of the world. The cat is an important reserv

What is biotechnology, What is biotechnology? The Biotechnology is the ...

What is biotechnology? The Biotechnology is the application of biological knowledge to obtain new techniques, materials and compounds of pharmaceutical, medical, agrarian, indu

What is the approximate number of amino acids, What would be the approximat...

What would be the approximate number of amino acids of a protein with a mass of 203 kd? Assume an average molecular weight for amino acids of 110 grams/mol.

Anaphase, Anaphase This  phase is of shortest duration. It  begins  wit...

Anaphase This  phase is of shortest duration. It  begins  with  a sudden  separation  of the two chromatids of each   due  to splitting   of its centromere and  then a slow mov

What is radiographic template, What is Radiographic Template Radiograp...

What is Radiographic Template Radiographic Template : You should always use it while taking a panoramic radiograph of the patient. It is done to counter the effect of magnific

Illustrate the term cilia, Illustrate the term Cilia? A cellular hairli...

Illustrate the term Cilia? A cellular hairlike locomotory structure which comprises an extension of the plasma membrane surrounding a 9+2 organization of microtubules. Unlike f

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd