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Which of the following defines why the vast majority of segregation errors in human patients include the two sex chromosomes (XXY, XO, XYY) or chromosome 21 (triple 21)?
A. The centromeres of these three chromosomes lack attachment sites for spindle microtubules therefore leading to a higher than normal segregation error rate.
B. These three chromosomes have the highest probability to be mis-segregated during anaphase I and II of meiosis.
C. Cells are more likely to survive with abnormal numbers of these three chromosomes whereas segregation errors of the other 20 human chromosomes are completely lethal.
D. Chromosome 21 as well as both sex chromosomes lack sequences that are recognized by proteins of the spindle assembly checkpoint (SAC). Thus the cell proceeds to anaphase even if these three chromosomes have failed to reach the metaphase plate.
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