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Interim analyses: An analysis made before the planned end of a clinical trial, typically with the aim of detecting the treatment differences at the early stage and thus preventing as many number of patients as possible receiving an 'inferior' treatment. Such type of analyses is often problematical particularly if carried out in the haphazard and unplanned trend.
Behrens Fisher problem : The difficulty of testing for the equality of the means of the two normal distributions which do not have the equal variance. Various test statistics have
It is the survey which is carried out in Great Britain on a continuous basis since 1971. About 100 000 households are included in this sample every year. The main goal of the surve
Link functions: The link function relates the linear predictor ηi to the expected value of the data. In classical linear models the mean and the linear predictor are identical
Hello-goodbye effect : The phenomenon initially described in psychotherapy research, but one which might arise whenever a subject is assessed on two occasions, with some interventi
Continual reassessment method: An approach which applies Bayesian inference for determining the maximum tolerated dose in a phase I trial. The method starts by assuming a logistic
A term usually used for unobserved individual heterogeneity. Such variation is of main concern in the medical statistics particularly in the analysis of the survival times where ha
Outliers - Reasons for Screening Data Outliers are due to data entry errors, subject is not a member of the population that the sample is trying to represent, or the subject i
Centile reference charts : Charts which are used inmedicine to observe the clinical measurements on individual patients in the context of the population values. If the population i
Discuss the use of dummy variables in both multiple linear regression and non-linear regression. Give examples if possible
methods of measuring trend
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