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Explain Fomivirsen
Fomivirsen, an antisense oligonu- cleotide, is FDA-approved for intravitreal treatment of CMV retinitis in HIV-infected patients who cannot tolerate or have not responded to other drugs. The manufacturer recommends not giving fomivirsen to patients who have been treated with cidofovir in the previous 2 to 4 weeks because of increased risk of ocular inflammation. The most commonly reported adverse effects include iritis, vitritis, enhanced intraocular pressure and vision changes. In vivo resistance has not been observed
The general mechanism of RNA synthesis by these eukaryotic RNA polymerases is the same as for the prokaryotic enzyme that is: ? The initiation of RNA synthesis by RNA polyme
GENETIC TERMINOLOGY (i) Gene - Mendel used the term factor for a gene. A gene is the unit of DNA responsible for the appearance and inheritance of character. (ii)
Can enhancers work in trans? That is, can an enhancer on one piece of DNA activate a promoter on another piece of DNA. Propose an experiment to test this. Be sure to discuss any ap
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Why is sub-culturing essential in plant tissue culture? Explain the process of heterosis. How is it dissimilar from inbreeding depression? Where and how is urea produced in
what are fats
Define the Vitamin and Minerals required for elderly? Decreased gastric secretion and intestinal motility affect the absorption and intake of nutrients especially calcium, iron
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How Infections and Infestations cause PEM? Childhood infections (viral/bacterial) and parasitic infestations are almost always associated with PEM. These cause anorexia (loss o
Fracture - It is a break of a bone. Bone fracture are of many types - (i) Green stick fracture - It is merely a crack, the bone remains partly intact. (ii ) Sim
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