Explain Clinical stigmata of specific syndromes in heart disease?

Clinical stigmata of specific syndromes: Evidence of preseilce of chromosoinal anomalies or other syndromes that are known to be associated with CHD should alert the clinician to the presence of specific cardiac defects that we known to be associated with these conditions. The list of such conditions is a long one. Trisomy 21 is the commonest chromosomal anomaly that is associated with heart disease. Other common examples include: trisomy 13, trisomy 18, Turner's Syndrome, Noonan's Syndrome, Velocardiofacial and the Di-Georges's Syndrome.