Activators

Activity  of many  enzymes is  influenced by  certain ions called as activators. Large number of enzymes such as hexokinase that require ATF are also in need of divalent =cations  like  M+  or  n".  Many enzymes such  as ATPase  require  monovalent cations like Na+, K'  or N&'  for maximum catalytic activity. Amylase  requires C1-.  - Generally, these ions interact with the substrates so that the substrates  can bind with the  catalytic  sites of  the  enzyme properly. Thus,  in  absence of the activators,  the enzymes become inactive or sluggish.