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Adverse Effects
The most common adverse effects of itraconazole are dose-related nausea and abdominal discomfort. Rash and serious hepatic toxicity can happen. The drug can cause hypokalemia, edema and hyper-tension. Congestive heart failure has been reported with itraconazole and the drug should not be used in patients with ventricular dysfunction.
Thrombocytopenia and leukopenia have also been reported. The intra-venous formulation have cyclodextrin, which can accumulate in azotemic patients; its use is not recommended in patients with creatinine clearance <30 mL/min.
Q. Derive Gorlin Formula? Formula I: First Hydraulic Formula (Toricelli's law) F = AVCc Where, F = flow rate A = orifice area Cc = coefficient of orifice cont
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This species is an ornamental tree in China, and has yielded the clinically active agents topotecan, irinotecan, and 9 -aminocamptothecin, which are semisynthetically derived from
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