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Assignment:
Connolly, a 4-month-old infant, presents for a complete physical examination and vaccinations. The examination was entirely normal. The second doses of DTaP, Hib, PCV13, and IPV were given. His mother called at 2:30 pm saying he had a temperature of 101.7°F (38.7°C) and was not eating well. She was instructed to administer acetaminophen and observe him. She called back at 4:45 pm indicating that he was limp and inactive. He was referred to the emergency department and found to be pale and listless. Physical examination showed a pale, inactive 4-month-old with a temperature of 103.6°F (39.2°C), decreased reaction to painful stimuli, and hypotonicity. Laboratory studies were normal. After 2 hours in the emergency department, he began to improve and started drinking from his bottle. He was sent home. The next day, the office nurse called his mother and found that he was active and playing.
1. Which vaccine is most likely to have been responsible for the adverse events?
2. Should Connolly receive another dose of this vaccine?
3. Do these adverse events need to be reported and if so to whom?
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