Same molecule to effectively neutralize antiviral activities

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Reference no: EM133934485

Questions

1. Viral proteins that block the host antivirus defense often target the same molecule to effectively neutralize antiviral activities. PKR is one such molecular target. Describe three ways by which the activity of PKR is neutralized as a consequence of virus infection.

2. An adenovirus mutant lacking the gene for VA-RNA I replicates poorly in human cells because viral protein synthesis is inefficient. When the same viral mutant is used to infect human cells lacking the gene encoding PKR, viral protein synthesis and the yield of infectious virus are both normal.

a. Explain why the adenovirus VA-RNA I mutant replicates poorly.

b. Why does the adenovirus VA-RNA I mutant grow normally in cells lacking the pkr gene?

3. What is the first viral biosynthetic process that takes place when a viral DNA genome enters an infected cell? Why must this process be the first to occur?

Reference no: EM133934485

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