Primers for retroviral reverse transcriptase polymerase

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Reference no: EM133933943

Questions

1. How did retroviruses acquire their name? What universally accepted concept concerning genetic information flow did they amend?

Why may retroviruses contain two RNA genomes? What other genetic information might they capture, and why may this be important?

What are the primers for the retroviral reverse transcriptase polymerase? Why are there several "exchanges" on the template? How does the DNA product differ from the RNA template?

2. What enzymes does HIV-1 encode and how is each employed?

3. What are the functions of RNase H and integrase during retroviral genome replication?

4. Which enzyme produces viral mRNAs in a cell infected with a retrovirus? What role do the LTRs play in this process?

5. What are the distinct roles for host transcription factors and the viral Tat protein in HIV gene expression?

Nearly half of your DNA consists of mobile genetic elements. What is their relationship to retroviruses? Are they of any use to us?

Hepadnaviruses and retroviruses both encode reverse transcriptase, yet the retroviral virion contains a (+) single-stranded RNA inside while the hepadnaviral virion contains a gapped double-stranded DNA molecule. How does this happen?

Does the hepadnavirus genome encode an RNase H? An integrase? Why or why not?

Why are viral reverse transcriptases error-prone? What are the medical implications of this property?

Reference no: EM133933943

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