Kidneys play vital role in maintaining homeostasis

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The kidneys play a vital role in maintaining homeostasis by filtering waste products, balancing electrolytes, and regulating blood pressure. Disruptions in kidney function can lead to significant health issues, primarily categorized into Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD). The development of chronic kidney disease (CKD) as a progression from acute kidney injury (AKI) has gained significant attention in recent research. This transition highlights a critical and often preventable pathophysiological pathway that can lead to long-term kidney impairment (Guzzi et al., 2018) The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) involves several interconnected pathophysiological mechanisms that contribute to the progression of kidney damage. Key features common to both conditions include microvascular integrity, changes in leukocyte and pericyte behavior, and the survival and function of tubular cells (Guzzi et al., 2018) Endothelial Dysfunction: In AKI, endothelial dysfunction leads to vasoconstriction and vascular congestion, reducing blood flow and oxygen delivery to the kidneys. This exacerbates kidney injury and sets the stage for CKD by promoting inflammation and fibrosis (Rogers, 2023).

Reference no: EM133875386

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