Reference no: EM133864616

Questions:

1. Identify why pediatric patients show greater drug sensitivity; and at what ages this sensitivity is the most pronounced.
2. Discuss how decreased protein binding of drugs in infants results in altered drug levels compared to adults, and how that, in turn, alters dosages.
3. Describe how the blood-brain barrier differs in infants vs adults; how that affects drug sensitivity; and how that in turn alters dosages.
4. Describe how liver function differs in infants vs adults; how that affects drug metabolism; and how that in turn alters dosages.
5. Describe how kidney function differs in infants vs adults; how that affects drug excretion; and how that in turn alters dosages.
6. Describe how pediatric dosages are determined if there is no established pediatric dose; their relationship to BSA; , and why they may be altered during course of treatment.
7. Identify why older patients show greater drug sensitivity; and the four main reasons this occurs.
8. Identify the four major factors that alter drug distribution in older adults.
9. Identify the changes to the liver as we age; and the possible consequences to drug levels that result.
10. Identify the changes to the kidney as we age; the consequences to drug levels that result; and the results that follow.
11. Discuss adverse drug reactions (ADRS) in older adults and identify the multiple factors that predispose older people to ADRs.