Explain restrictive cardiomyopathy, Biology

Assignment Help:

Q. Explain Restrictive cardiomyopathy?

It is a systemic or idiopathic disorder of the myocardium with clinical and hemodynamic features of diastolic dysfunction, closely simulating constrictive pericarditis. Restrictive cardiomyopathes could be myocardial or endomyocardial. The former could be noninfiltrative (e.g., idiopathic or familial), infiltrative (e.g., amyloidosis) or storage (e.g., hemochromatosis). The endomyocardial group could be obliterative (e.g., Endomyocardial Fibrosis) or nonobliterative (e.g., radiation, drugs).

Clinical Menifestation

The symptoms are those of pulmonary and systemic congestion viz. Dyspnoea, nocturnal dyspnoea, ankle edema, abdominal discomfort. The findings are those of raised filling pressures on two sides of heart - Raised JVP with prominent X and Y descent. (Y is more prominent than X), enlarged tender liver and ankle edema, and also signs of pulmonary venous congestion viz. S3, rales over both lungs.

Electrocardiography

It is always abnormal. LBBB is common but RBBB also can occur. There may be cardiac arrhythmias. Atrial fibrillation is common. Low voltage occurs in cardiac amyloidosis.

X-Ray Chest

There are two major features (1) Absence of cardiomegaly (2) signs of pulmonary venous hypertension.

2D Echocardiography

The heart is only minimally dilated and there is no thickening of the myocardium in idiopathic causes, but may be thickened in infiltrative disorders. Both atria are enlarged. The filling pattern on Doppler may simulate that of constrictive pericarditis, but early rapid filling is more rapid in some. Prominent E-wave suggests that. It also has severely reduced deceleration time indicative of raised left atrial pressure. LV thickness is usually less than 1.7cm. Ventricular systolic function is normal. LVED volume is not more than 110 ml/m2 and LV end diastolic dimension in not more than 6 cm.

In endomycardial fibrosis, there is diminution of ventricular volumes, frequently associated with complete obliteration of apices of both ventricles.


Related Discussions:- Explain restrictive cardiomyopathy

Apex locator in retreatment cases-endodontics principles, Apex locator in r...

Apex locator in retreatment cases: -    Electronic apex locators may give misread for working length when gutta-percha is initially being removed. -    Due to that file beging

Explain highly active antiretroviral therapy, Highly active antiretroviral ...

Highly active antiretroviral therapy (HAART) - The treatment of HIV infection requires combination therapy known as highly active antiretroviral therapy (HAART) along with inte

Wigs and hairs - seed appendages, Wigs and hairs - Seed Appendages Se...

Wigs and hairs - Seed Appendages Seeds of certain plants have epidermal outgrowths or the integuments themselves may form folds and projections that present a wing-like appea

Explain counseling strategies, Counseling Strategies The counseling str...

Counseling Strategies The counseling strategies which may serve  lo be useful are described herewith. Individual Counseling: Individual counseling is personal counseling.  T

Infection - complications of cardiac surgery, Infection Due to the m...

Infection Due to the many invasive monitoring techniques, ET tube, urinary catheter, surgical interventions. Cultures of blood or sputum/urine/swab form the wound is don

What are the symptoms of acute pericarditis, Q. What are the Symptoms of ac...

Q. What are the Symptoms of acute pericarditis? Chest Pain Chest pain is the most important symptom. It is retrosternal in location and patient usually locates the site o

Explain database search, Database Search: Once an open reading frame or th...

Database Search: Once an open reading frame or the partial amino acid sequence has been pre-determined, the investigator compares sequence with others in the databases using a com

Fungi, what is primitive fungi?

what is primitive fungi?

What are the female pronucleus, What are the female pronucleus and the male...

What are the female pronucleus and the male pronucleus? The female pronucleus is the proper haploid nucleus of the egg cell. Male pronucleus is the haploid nucleus of the sperm

What are the main components of the cytoskeleton, The cytoskeleton is a net...

The cytoskeleton is a network of very little tubules and filaments spread throughout the cytoplasm of eukaryotic cells. It is made of microtubules, microfilaments and intermediate

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd