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Define role of Leptin in controlling gene expression?
Leptin is a protein product (containing 167 amino acids) of the ob gene expressed exclusively in the adipose tissue. This protein molecule functions as an afferent signal in a negative feedback loop, centred in the hypothalamus, regulating the size of the adipose tissue mass.Leptin has been shown to modulate the synthesis of neuropeptides, particularly Neuropeptide Y (NPY) that regulates food intake. Increases energy expenditure as indicated by animal experiments. Leptin induced weight loss is completely specific for adipose tissue. While feeding does not appear to modulate leptin expression, fasting acutely decreases plasma leptin concentration. In general, obese humans have high leptin levels and the available data suggest that human obesity is likely to be associated with insensitivity to leptin.
Q. What do you mean by Polyphagia? Increased Hunger (Polyphagia): As patient is losing more sugar in the urine, he feels hungry very soon and tends to take more food. It is cal
what is the difference between neurological and neurovascular observations
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In the year of 1953, Watson and Crick worked out the 3-D structure of DNA, beginning from X-ray diffraction photographs taken through Wilkins and Franklin. They decreased which D
How do organisms like:- a) fungi, b) zooplanktons and c) bears overcome the temporary short- lived climatic stressful conditions? Define.
Explain Potts Shunt in palliative operations ? This is a similar shunt done through a left thoracotomy. Anastomosis is done between left pulmonary artery aid descending thoraci
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