Ablation experiment is an experiment designed to produce an animal deficient in one or the few cell types, in order to study cell lineage or the cell function. The logic is to make a transgenic mouse with a toxin gene (often known as diphtheria toxin) under control of a specialized promoter which activates only in the target cell type. When the embryo development progresses to the point where it starts to form the target tissue, the toxin gene is activated, and that particular tissue dies. Other tissues are not affected.

Posted Date: 8/1/2012 7:01:21 AM | Location : United States

Ask an Expert

Related Discussions:- Ablation experiment, Assignment Help, Ask Question on Ablation experiment, Get Answer, Expert's Help, Ablation experiment Discussions

Write discussion on Ablation experiment
Your posts are moderated

Write your message here..

Related Questions

What food items include in clear liquid diet, What Food items include in cl... What Food items include in clear liquid diet -  Clear, fat free soups/broths -  Light coffee, tea (without milk or cream) -  Strained fruit juices -  Tender coconut wa

What is the secondary structure of a protein, The secondary protein structu... The secondary protein structure is produced by the manner its amino acids interact by intermolecular bond. These interactions make a spatial conformation of the polypeptide filamen

How does biogeography contribute to an evolution, How does biogeography con... How does biogeography contribute to an understanding of evolution? In biogeography studies, same animals that seem to be closely related are adapted to dissimilar environments

How rb proteins phosphorylation affects the cell cycle, How Rb protein's ph... How Rb protein's phosphorylation state affects the cell cycle and cancer progression. please put link or citation of where you find information.

What is constitutional unit of proteins, Q. What is constitutional unit of ... Q. What is constitutional unit of proteins? The constitutional units of proteins are the amino acids.

What are biological troubles, What are the biological troubles that mollusc... What are the biological troubles that molluscs face due to their soft body? Because molluscs have a soft body they are more fragile. They also have more complexity to support t

Which animals maintain constant body temperature?, Which of the below terms... Which of the below terms is used to describe animals which maintain a constant body temperature by producing heat by metabolic oxidations (muscle contractions) and losing excess he

Impulse in the sensory neurone, Explain briefly how the stimulus at the fin... Explain briefly how the stimulus at the finger produces an impulse in the sensory neurone using the following key words. 1. Energy conversion (linked to receptor) 2. Na+ in 3. Depo

Explain about the alitame - artificial sweeteners, Explain about the Alitam... Explain about the Alitame - artificial sweeteners? Alitame (L-α-aspartyl-N-(2, 2, 4, 4-tetramethyl-3-thietanyl)-D-alaninamide), as illustrated in figure, is a sweetener based o

Differentiate between the five kingdoms of organisms, Question 1: (a) G... Question 1: (a) Give, in order, the major categories of taxonomic classification. (b) Differentiate between the five kingdoms of organisms. (c) Differentiate between net