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When the chromosomes are depleted of histones they are seem to have a central fibrous 'protein scaffold' or nuclear matrix to which the DNA is attached in loops. Therefore, in vivo it seems like in which the next order of packaging have the attachment of the 30 nm fiber to multiple locations on this central protein scaffold in a series of radial loops. Little is known to how this structure is structured.
figure: Attachment of the 30nm fiber to a central protein scaffold with the loops arranged radially around the scaffold. The diagram on the right represent a representational cross-section bya chromosome.
If children obtain half their genes from one parent and half from the other parent, why aren't siblings identical?
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