What is phenylketonuria, Biology

Assignment Help:

Q. What is Phenylketonuria?

The essential amino acid phenylketonuria is utilized for tissue protein synthesis and hydroxylated to form tyrosine. The hydroxylation reaction requires phenylalanine hydroxylase. Phenylketonuria (PKU) is a group of inherited disorders of phenylalanine metabolism caused by impaired phenylulanine hydroxylase activity. PKU cannot break down phenylalanine into another amino acid, tyrosine. Phenylalanine then builds up in the bloodstream and causes brain damage.

Phenylketonuria, commonly referred to as PKU, occurs at the age of 3 to 6 months and is characterized by developmental delay, microcephaly (abnormally small head), abnormal electro-encephalogram, eczema, musty odour and hyper activity. Lf untreated before three weeks of age, the metabolic imbalance produces irreversible mental retardation. The defect in metabolism in classic PKU is associated with less than 2% activity of normal phenylalanine hydroxylase.


Related Discussions:- What is phenylketonuria

How we can do karyotype analysis, Why in the preparation of a karyotype ana...

Why in the preparation of a karyotype analysis is the use of a substance like colchicine interesting? Colchicine is a substance that disallows the formation of microtubules and

Define the causes of instrument fracture, Define the Causes of Instrument F...

Define the Causes of Instrument Fracture Too much apical pressure ( specially in narrow or curved canal) Used in dry canal without irrigation or lubricant Excessi

What purpose does sleep serve for the brain, What purpose does sleep serve ...

What purpose does sleep serve for the brain? A. We don't yet know full answer to this fundamental question however neuroscience is providing intriguing clues. It's increasingly

Chordates, what are the general characters of chordates? At least 10 charac...

what are the general characters of chordates? At least 10 characters.

Which of substance are microtubules, Q Which Of substance are microtubules ...

Q Which Of substance are microtubules made and In which structures and cellular processes do microtubules participate? Microtubules are made of consecutive dimers of the protei

PHYLUM ANNELIDA, GERENAL CHARACTERICS OF PHYLUM ANNELIDA

GERENAL CHARACTERICS OF PHYLUM ANNELIDA

B -pleated sheets protein structure, β - Pleated Sheets In this in...

β - Pleated Sheets In this inter molecular hydrogen bonds are present Two or more polypeptide chains come together and from a sheet. Condensation in little. However

Biochemistry pathway of normal and cancer cell, Biochemistry pathway of nor...

Biochemistry pathway of normal and cancer cell Normal cells will separate within the presence of a chemical signal like as "growth factor" (GF). Other molecular signals

Control of pollution, Control of Pollution We have seen that pollution...

Control of Pollution We have seen that pollution affects human health, 'vegetation, crop yield, trees, fisheries, forests, buildings, archaeological monuments, tourism. These

Differences between prokaryotes and eukaryotes, Differences between Prokary...

Differences between Prokaryotes and Eukaryotes It is obvious that there are a number of differences between them. Prokaryotes, like bacterial cells are generally much smaller,

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd