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Q. What are the major theoretical models that try to explain the formation of the enzyme-substrate complex?
There are two major models that explain the formation of the enzyme-substrate complex: the key and lock model and the induced fit model. In the key and lock model the enzyme has a region with specific spatial conformation for the binding of the substrate. In the induced fit model the binding of the substrate induces a alteration in the spatial configuration of the enzyme for the substrate to fit.
Once the decision to start drug treatment of hypertension is made, the aim should be to provide 24 hour BP control, with agents that would encourage patient adherence. The patient
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