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Q. What are the major theoretical models that try to explain the formation of the enzyme-substrate complex?
There are two major models that explain the formation of the enzyme-substrate complex: the key and lock model and the induced fit model. In the key and lock model the enzyme has a region with specific spatial conformation for the binding of the substrate. In the induced fit model the binding of the substrate induces a alteration in the spatial configuration of the enzyme for the substrate to fit.
This problem refers to the MN and ABO loci mentioned in class. It also refers to the Rh locus, which is responsible for the positive/negative part of the blood type. The Rh+ allele
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