Rational in individual patient, Biology

Assignment Help:

Thiazide diuretics have been accepted as the primary foundation of antihypertensive therapy. The basis of this choice is that, apart from their primary hypotensive effect, they enhance the efficacy of other hypotensive drugs. It has been observed that most of the hypertensive patients would require 2 or more drugs for optimal control. Usually another drug from a different class can be added when BP is more than 20/10 above the goal. The drugs can be administered either separately or as fixed dose combinations. The presence of comorbid conditions should determine the choice of specific classes of hypotensive drugs.

a) Ischemic Heart Disease

In patients with hypertension and stable angina the drug of choice is usually a beta-blocker, with or without a long acting calcium channel blocker. In unstable angina, a beta-blocker, diltiazem and ACE inhibitors or an ARB are the preferred ones. In post infarction states beta-blockers and ACEI/ARB are the choices.

b) Heart Failure

With the current interest in diastolic heart failure there is a greater interest in the management of diastolic dysfunction usually detected on echocardiography. Beta-blockers and ACEI/ARB are the choices. Diuretics are not recommended since they decrease the LV filling pressure. In early systolic dysfunction, ACE/ARB are given. In florid heart failure it has to be diuretics, aldosterone antagonists, ARB/ACEI are recommended.

c) Diabetic with Hypertension

ACEI and ARBs are first choice since they have been found to retard the progression of diabetic nephropathy and may reduce albuminuria. Other drugs can be added to obtain the target BP of 130/80.


Related Discussions:- Rational in individual patient

What is the cell theory, Q. What is the cell theory? Cell theory assert...

Q. What is the cell theory? Cell theory asserts that the cell is the element unit of living beings. Before the discovery of the cell, it was not acknowledged that living bei

Soyabean and sesame proteins - mutual supplementation, Define Soyabean and ...

Define Soyabean and sesame proteins - mutual supplementation of Protein? Soyabean and sesame proteins: Soyabean proteins are good sources of lysine but are deficient in methion

Define conjunctival xerosis - micronutrient deficiencies, Define Conjunctiv...

Define Conjunctival Xerosis - Micronutrient Deficiencies? Conjunctiva in nonnal children is bright white, smooth and glistening. Conjunctival xerosis is characterized by drynes

What will happen to membranes, What might happen to membranes if many -OH g...

What might happen to membranes if many -OH groups were added to the tails of phospholipids?

Sausage manufacture - meat products, Sa u s a g e manufacture Saus...

Sa u s a g e manufacture Sausage enjoys a prime place among various meat products. Major advancements in processing technology (rapid curing, hot processing, use of solubl

Explain the multiple organ dysfunction syndrome (mods), Explain the Multipl...

Explain the Multiple Organ Dysfunction Syndrome (MODS) Failure of essential organs is the most severe complication of sepsis and may result in death. The treatment of systemic

Define intentional adulteration - types of adulteration, Define Intentional...

Define Intentional Adulteration - Types of Adulteration? In intentional adulteration, the substance is added, removed or substitute knowingly by the adulterator for the purpose

Tolerance range, Maximum and minimum range of an animal with the factors of...

Maximum and minimum range of an animal with the factors of Ph Salinity Pressure Relative human

What is population growth rate, What is population growth rate? Populat...

What is population growth rate? Population growth rate (PGR) is the percent variation among the number of individuals in a population at two different times. Thus the populatio

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd