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Pathophysiology
Infective endocarditis occurs when turbulence within the heart allows causative organism to infect previously damaged valves or other endothelial surfaces.
Vegetations consisting of fibrin, leukosytes, platelets and microbes adhere to the valve surface or endocardium. The loss of portions of the friable vegetations into the circulation result in embolization. Infection spread to heart valves leads to valvular incompetence, CHF, generalized myocardial dysfunction and sepsis.
Will there be an opportunity to comment? In a supplemental notice accompanying the last rule package, EPA is soliciting additional information and public comment on issues fro
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