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Pathophysiology
Infective endocarditis occurs when turbulence within the heart allows causative organism to infect previously damaged valves or other endothelial surfaces.
Vegetations consisting of fibrin, leukosytes, platelets and microbes adhere to the valve surface or endocardium. The loss of portions of the friable vegetations into the circulation result in embolization. Infection spread to heart valves leads to valvular incompetence, CHF, generalized myocardial dysfunction and sepsis.
Medical status of the patient Conditions like osteoporosis, history of radiotherapy, use of bisphosphonates which can affect the success of the treatment should be considered b
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