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The extracellular surface of the plasma membrane is frequently covered with a protective coat of carbohydrate. A Sugar residue of this carbohydrate coat can be friendly either to certain lipids like as the glycosphingolipids, or to the polypeptide chains of peripheral or integral membrane proteins. These glycoprotein's and glycolipids are abundant in the plasma membrane of eukaryotic cells but are almost absent from most intracellular membranes, mainly the chloroplast lamellae and the inner mitochondrial membrane. In glycoprotein the sugar residues can be friendly to the polypeptide chain either by the hydroxyl group in the side-chain of Ser or Thr residues as O-linked oligosaccharides, or by the amide set in the side-chain of Asn as N-linked oligosaccharides. The carbohydrate on the extracellular face of the membrane not only gives a protective role but is also having in intercellular recognition and in preserve the asymmetry of the membrane.
figure: The erythrocyte cytoskeleton
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