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Last observation carried forward is a technique for replacing the observations of the patients who drop out of the clinical trial carried out over a time period. It consists of substituting for each missing value the subject's last available assessment of same type. Though widely applied, particularly in the pharmaceutical industry, its use is very limited since it makes very improbable assumptions about the data, for instance, that the (unobserved) post drop-out response are frozen at the last observed value.
Mendelian randomization is the term applied to the random assortment of alleles at the time of gamete formation, a process which results in the population distributions of genetic
Common cause failures (CCF): Simultaneous failures of the number of components due to a same reason. A reason can be external to the components, or it can be the single failure wh
An approach to investigations designed to recognize a particular medical condition in the large population, usually by means of a blood test, which might result in the considerable
Interim analyses : An analysis made before the planned end of a clinical trial, typically with the aim of detecting the treatment differences at the early stage and thus preventing
Randomization tests are the procedures for determining the statistical significance directly from the data with- out recourse to some particular sampling distribution. For instanc
The plot of the number of cases of the disease against the time period. A large and sudden increase corresponds to an epidemic. The example of this is shown in the figure drawn bel
Chebyshev's inequality: A statement about the proportion of the observations which fall within some number of the standard deviations of the mean for any of the probability distri
Nested design is the design in which levels of one or more factors are subsampled within one or more other factors such that, for instance, each level of a factor B happens at onl
The method or technique for producing the sequence of parameter estimates that, under the mild regularity conditions, converges to maximum likelihood estimator. Of particular signi
Independent component analysis (ICA) is the technique for analyzing the complex measured quantities thought to be mixtures of other more fundamental quantities, into their fundamen
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