Explain the bioavailability of folate, Biology

Assignment Help:

Explain the Bioavailability of Folate?

Bioavailability of folate from naturally occurring food sources is variable and frequently incomplete, as mentioned earlier in the food sources section. The bioavailability of natural folates is affected by the removal of the polyglutamate chain by the intestinal conjugase. This process is apparently not complete, thereby reducing the bioavailability of natural folates by as much as 25-5096. In contrast, synthetic folic acid appears to be highly bio available- 85% or greater. The low bioavailability and, more importantly, the poor chemical stability of the natural folates have a profound influence on the development of nutrient recommendations. This is particularly true if some of the dietary intake is as stable and bio available as the synthetic fonn, folic acid. Fortification of foods such as breakfast cereals and flour can add significant amounts of folic acid to the diet.

Since folic acid (synthetic) taken with food is 85% bio available but food folate is only about 50% bio available, folic acid taken with food is 85150 (i.e. 1.7) times more  available. Thus, if a mixture of synthetic folic acid plus food folate bas been fed, dietary folate equivalents (DFEs) are calculated as follows to determine the EAR:

yg of DFE provided = [mg of food folate + (1.7 x mg of synthetic folic acid)].

To be comparable to food folate, only half as much folic acid is needed if taken on an empty stomach, i.e. lpg of DFE: = lmg of food folate = 0.5 mg of folic acid taken on an empty stomach = 0.6 mg of folic acid with meals.

Alcohol interferes with the absorption of folate and increases excretion of folate by the kidney.


Related Discussions:- Explain the bioavailability of folate

Temperature and concentration of nutrients, Temperature and Concentration o...

Temperature and Concentration of Nutrients Temperature Temperature like salinity remains almost constant in the oceans in contrast to the land or terrestrial ecosystems

Functions of ecosystem, Ecosystems main functions are physical, chemical an...

Ecosystems main functions are physical, chemical and biological processes. Which is required for if maintenance of ecosystem. Some important function- 1.        Production of bi

Define role in growth and cellular differentiation, Define Role in growth a...

Define Role in growth and cellular Differentiation? The growth and differentiation of epithelial cells throughout the body are especially affected by vitamin A deficiency.  In

Understanding behaviour of diabetic patients, Q. Understanding Behaviour of...

Q. Understanding Behaviour of diabetic patients? Beliefs  Each of us has a set of beliefs that were learned by us when we were young. These include religious beliefs and

Nervous tissue, This constitutes about 2.4% of the body weight of man viz. ...

This constitutes about 2.4% of the body weight of man viz. Brain-1400 gram Spinal nerve-150 gram Spinal cord-30 gram Cranial nerve-10 gram C.S.F. is altogether not present in

Explain the term health, Explain the term 'health' Mention any two ways of ...

Explain the term 'health' Mention any two ways of maintaining it. Why does a doctor administer tetanus antitoxin and not a tetanus vaccine to a child Injured in a roadside acci

Classification of anaemia based on etiology, Classification of Anaemias Bas...

Classification of Anaemias Based on Etiology   Anaemia  can be classified  as   Impaired Production of Red Blood Cells and Hemoglobin: This can be due to nutritional  def

Aujeszky''s disease, Aujeszky's disease This is primarily a disease of...

Aujeszky's disease This is primarily a disease of pigs, which serve as the principal reservoir host. The secondary hosts include cattle, horse, sheep, goat, dog and cat but hu

Denaturizing be classified regarding its reversibility, How can denaturizin...

How can denaturizing be classified regarding its reversibility? Ans) Protein denaturizing can be a reversible or irreversible process, i.e., it can be possible or impossible to

Explain the dna hybridisation, Explain the DNA Hybridisation? This tech...

Explain the DNA Hybridisation? This technique is used to study or compare the genetic affinity between two organism. In such studies the deoxyribonucleic acid (DNA) of both org

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd