Explain the bioavailability of folate, Biology

Assignment Help:

Explain the Bioavailability of Folate?

Bioavailability of folate from naturally occurring food sources is variable and frequently incomplete, as mentioned earlier in the food sources section. The bioavailability of natural folates is affected by the removal of the polyglutamate chain by the intestinal conjugase. This process is apparently not complete, thereby reducing the bioavailability of natural folates by as much as 25-5096. In contrast, synthetic folic acid appears to be highly bio available- 85% or greater. The low bioavailability and, more importantly, the poor chemical stability of the natural folates have a profound influence on the development of nutrient recommendations. This is particularly true if some of the dietary intake is as stable and bio available as the synthetic fonn, folic acid. Fortification of foods such as breakfast cereals and flour can add significant amounts of folic acid to the diet.

Since folic acid (synthetic) taken with food is 85% bio available but food folate is only about 50% bio available, folic acid taken with food is 85150 (i.e. 1.7) times more  available. Thus, if a mixture of synthetic folic acid plus food folate bas been fed, dietary folate equivalents (DFEs) are calculated as follows to determine the EAR:

yg of DFE provided = [mg of food folate + (1.7 x mg of synthetic folic acid)].

To be comparable to food folate, only half as much folic acid is needed if taken on an empty stomach, i.e. lpg of DFE: = lmg of food folate = 0.5 mg of folic acid taken on an empty stomach = 0.6 mg of folic acid with meals.

Alcohol interferes with the absorption of folate and increases excretion of folate by the kidney.


Related Discussions:- Explain the bioavailability of folate

Determine about the the halstead category test, Determine about the The Hal...

Determine about the The Halstead Category Test  This test is a concept identification procedure in which the subject must discover the method or principle that governs various

Morphological changes - floral induction, Morphological Changes - Floral In...

Morphological Changes - Floral Induction Some of the morphological changes that accompany floral induction are: Change in the shape of meristem, Increase in the ra

Explain nutrient requirement and dietary management, Explain Nutrient Requi...

Explain Nutrient Requirement and Dietary Management? You must have understood by the discussion above that by the end of the flow phase, the patient usually is well hydrated an

Some common air pollutants, The major air pollutants are: (i)     Carbo...

The major air pollutants are: (i)     Carbon monoxide, CO (ii)   Nitrogen oxides, (NO)x (iii) Sulphur oxide, (SO)x (iv) Ground level ozone (O3) (v)   Hydrocarbons (

Extracellular signals, extracellular signals and their characteristics

extracellular signals and their characteristics

Define methods for studying the nutrient requirements, Define Methods for S...

Define Methods for Studying the Nutrient Requirements? 1) Population survey of nutrient intakes of healthy individuals is one method of estimating nutrient requirements. The av

Slromal swelling pressure for corneal hydration, How is the responsible slr...

How is the responsible slromal swelling pressure for corneal hydration? Slromal Swelling Pressure Stromal Swelling Pressure (SSP) is the pressure exerted by GAG (Glycosa

Can you explaon about aortography, Q. Can you explaon about Aortography? ...

Q. Can you explaon about Aortography? Visualization of the aorta and its branches is possible by several modalities today. Apart from angiography, aorta can also be visualized

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd