Explain the bioavailability of folate, Biology

Assignment Help:

Explain the Bioavailability of Folate?

Bioavailability of folate from naturally occurring food sources is variable and frequently incomplete, as mentioned earlier in the food sources section. The bioavailability of natural folates is affected by the removal of the polyglutamate chain by the intestinal conjugase. This process is apparently not complete, thereby reducing the bioavailability of natural folates by as much as 25-5096. In contrast, synthetic folic acid appears to be highly bio available- 85% or greater. The low bioavailability and, more importantly, the poor chemical stability of the natural folates have a profound influence on the development of nutrient recommendations. This is particularly true if some of the dietary intake is as stable and bio available as the synthetic fonn, folic acid. Fortification of foods such as breakfast cereals and flour can add significant amounts of folic acid to the diet.

Since folic acid (synthetic) taken with food is 85% bio available but food folate is only about 50% bio available, folic acid taken with food is 85150 (i.e. 1.7) times more  available. Thus, if a mixture of synthetic folic acid plus food folate bas been fed, dietary folate equivalents (DFEs) are calculated as follows to determine the EAR:

yg of DFE provided = [mg of food folate + (1.7 x mg of synthetic folic acid)].

To be comparable to food folate, only half as much folic acid is needed if taken on an empty stomach, i.e. lpg of DFE: = lmg of food folate = 0.5 mg of folic acid taken on an empty stomach = 0.6 mg of folic acid with meals.

Alcohol interferes with the absorption of folate and increases excretion of folate by the kidney.


Related Discussions:- Explain the bioavailability of folate

Female reproductive system, FEMALE REPRODUCTIVE SYSTEM - In female mamm...

FEMALE REPRODUCTIVE SYSTEM - In female mammals the female reproductive system characteristically comprises of the ovary, uterus, placenta, vagina and vulva.

Describe how the international astronomical union defines, Describe how the...

Describe how the International Astronomical Union defines a planet. Also include why Pluto is no longer considered a planet.

Types of insulin, There are different types of insulin available and prescr...

There are different types of insulin available and prescribed by the doctor according to the need of the patient. Insulin is grouped according to the speed of action in the body i.

Explain wire loop and tube method, Explain Wire loop and Tube Method 1....

Explain Wire loop and Tube Method 1.  Use a 25-gauge dental injection needle, cut to remove beveled end 2. Both ends of-mm diameter steel ligature wire passed through the ne

How to calculate the raw score for each scale, How to calculate the raw sco...

How to calculate the raw score for each scale The raw score for each scale is the sum of the 0, 1 and 2 item scores. Thus, the higher the score, the poorer the performance. Th

Determine the concept of digestion of fats, Which of the following assist i...

Which of the following assist in the digestion of fats? A. Production of bile salts in the liver and the secretion of those bile salts into the small intestine. B. Emulsific

How does the body defend itself from microorganisms, Q. How does the body d...

Q. How does the body defend itself from microorganisms and other harmful substances that enter the airway during the breathing process? The epithelium of the airway is a ciliat

What is oxidative phosphorylation, What is oxidative phosphorylation? O...

What is oxidative phosphorylation? Oxidative phosphorylation is  the process by which ADP is phosphorylated by Pi  to ATP  in  the  respiratory chain.

Statements concerning the inheritance of a dominant trait, Which of the fol...

Which of the following statements concerning the inheritance of a dominant trait is true? Every affected person must have at least one affected parent. The trait is observed to ski

01.03 New Technology , What is the best microscope to get a detailed view o...

What is the best microscope to get a detailed view of the parts inside of a preserved plant cell? Transmission electron microscope Scanning electron microscope Compound li

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd