Explain the bioavailability of folate, Biology

Assignment Help:

Explain the Bioavailability of Folate?

Bioavailability of folate from naturally occurring food sources is variable and frequently incomplete, as mentioned earlier in the food sources section. The bioavailability of natural folates is affected by the removal of the polyglutamate chain by the intestinal conjugase. This process is apparently not complete, thereby reducing the bioavailability of natural folates by as much as 25-5096. In contrast, synthetic folic acid appears to be highly bio available- 85% or greater. The low bioavailability and, more importantly, the poor chemical stability of the natural folates have a profound influence on the development of nutrient recommendations. This is particularly true if some of the dietary intake is as stable and bio available as the synthetic fonn, folic acid. Fortification of foods such as breakfast cereals and flour can add significant amounts of folic acid to the diet.

Since folic acid (synthetic) taken with food is 85% bio available but food folate is only about 50% bio available, folic acid taken with food is 85150 (i.e. 1.7) times more  available. Thus, if a mixture of synthetic folic acid plus food folate bas been fed, dietary folate equivalents (DFEs) are calculated as follows to determine the EAR:

yg of DFE provided = [mg of food folate + (1.7 x mg of synthetic folic acid)].

To be comparable to food folate, only half as much folic acid is needed if taken on an empty stomach, i.e. lpg of DFE: = lmg of food folate = 0.5 mg of folic acid taken on an empty stomach = 0.6 mg of folic acid with meals.

Alcohol interferes with the absorption of folate and increases excretion of folate by the kidney.


Related Discussions:- Explain the bioavailability of folate

Explain enzymatic proteins, Explain Enzymatic Proteins The most varied ...

Explain Enzymatic Proteins The most varied and most highly specialized proteins are those with catalytic activity - the enzymes. Virtually all the chemical reactions of organic

Explain about the micronutrient deficiencies, Explain about the Micronutrie...

Explain about the Micronutrient Deficiencies? Micronutrient deficiencies are more common during calamities. Can you guess, why? This is due to the lack of diversified food item

How to dna fragments for comparison with other dna samples, DNA fingerprint...

DNA fingerprinting produces a unique banding pattern of DNA fragments for comparison with other DNA samples.

Explain lactate dehydrogenase, Lactate dehydrogenase (LDH) is one of the im...

Lactate dehydrogenase (LDH) is one of the important enzymes in glycolysis which catalyzes the interconversion of pyruvate and lactate as follows:   Functional lactate d

What proportion of changes in the third position, If a codon is CDC, what p...

If a codon is CDC, what proportion of nucleotide changes in the third position result in a new amino acid? If the codon is AGG, what proportion of changes in the first position res

Define changes associated with the skeletal system - ageing, Define Changes...

Define Changes associated with the skeletal system - Ageing? Skeletal bone loss occurs with ageing and may have serious consequences among the elderly. With ageing, there is so

What are the factors that limit ability to fully classify, What are the fac...

What are the factors that limit our ability to fully classify and understand microbial diversity and what implications do these challenges have for environmental and health managem

What factor contributed to the current variations, According to the theory ...

According to the theory of natural selection, what factor below contributed to the current variations in beak sizes of finch species on the Galapagos Islands? a. Finches dispersed

Excretion in cockroach, EXCRETIO N IN COCKROACH- Animal is uricotelic....

EXCRETIO N IN COCKROACH- Animal is uricotelic. Excretory organs are malphighian tubules. 60-150 in 6-8 groups. In each group 10-15. Yellow coloured, blind tube, open in gut

Blood circulation and respiration, A person is declared to be dead upon the...

A person is declared to be dead upon the irreversible cessation of spontaneous body functions: brain activity, or blood circulation and respiration. However, only about 1% of a per

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd