Explain the bioavailability of folate, Biology

Assignment Help:

Explain the Bioavailability of Folate?

Bioavailability of folate from naturally occurring food sources is variable and frequently incomplete, as mentioned earlier in the food sources section. The bioavailability of natural folates is affected by the removal of the polyglutamate chain by the intestinal conjugase. This process is apparently not complete, thereby reducing the bioavailability of natural folates by as much as 25-5096. In contrast, synthetic folic acid appears to be highly bio available- 85% or greater. The low bioavailability and, more importantly, the poor chemical stability of the natural folates have a profound influence on the development of nutrient recommendations. This is particularly true if some of the dietary intake is as stable and bio available as the synthetic fonn, folic acid. Fortification of foods such as breakfast cereals and flour can add significant amounts of folic acid to the diet.

Since folic acid (synthetic) taken with food is 85% bio available but food folate is only about 50% bio available, folic acid taken with food is 85150 (i.e. 1.7) times more  available. Thus, if a mixture of synthetic folic acid plus food folate bas been fed, dietary folate equivalents (DFEs) are calculated as follows to determine the EAR:

yg of DFE provided = [mg of food folate + (1.7 x mg of synthetic folic acid)].

To be comparable to food folate, only half as much folic acid is needed if taken on an empty stomach, i.e. lpg of DFE: = lmg of food folate = 0.5 mg of folic acid taken on an empty stomach = 0.6 mg of folic acid with meals.

Alcohol interferes with the absorption of folate and increases excretion of folate by the kidney.


Related Discussions:- Explain the bioavailability of folate

Where do the photochemical stages of photosynthesis occur, Where do the pho...

Where do the photochemical and the chemical stages of photosynthesis occur? The photochemical stage of the photosynthesis process happens mainly on the thylakoids (the green pa

Determine the types of exercises, Determine the Types of Exercises Exer...

Determine the Types of Exercises Exercises are generally grouped  into three types: - Flexibility exercises such as stretching improves the range of motion of muscles and jo

Find cellular machinery for the replication of nucleic acids, Which of the ...

Which of the following statements is true? Answer Viruses are distinct from cells by the absence of a lipid membrane around them. Viruses are parasites that require the cell's meta

The social environment - stress of hospitalization, The Social Environment ...

The Social Environment   When the child is admitted to the hospital his social environment is totally changed and all health team members are strangers for him. It is your resp

Explain nutritional and functional role of aluminium, Minerals :- Aluminium...

Minerals :- Aluminium                Food Source       Low and variable in foods, component of some antacids and leavening agents Nutritional Functional role Possib

Factors limiting the productivity of aquatic habitats, Factors Limiting the...

Factors Limiting the Productivity of Aquatic Habitats Sunlight and oxygen are the two most important limiting factors of the aquatic ecosystems. This distinguishes them from t

Find the net charge of the predominant form asp, Determine the net charge o...

Determine the net charge of the predominant form Asp at (a) pH 1.0, (b) pH 3.0, (c) pH 6.0, and (d) pH 11.0?

Describe metabolic syndrome, Describe Metabolic Syndrome ? As discussed...

Describe Metabolic Syndrome ? As discussed, the risk factors like obesity, high blood pressure, high blood glucose or impaired glucose tolerance, and dyslipidaeinia are very im

Explain bleeding on probing, Bleeding on Probing (BOP) BOP when elicite...

Bleeding on Probing (BOP) BOP when elicited (notated in patient record as BOP +) after the insertion of a probe into the sulcus with light pressure i.e. 25 N has been shown to

What is the type of genetic inheritance of daltonism, What is the type of g...

What is the type of genetic inheritance of daltonism? Is daltonism more frequent in men or in women? What is the physiological explanation for the daltonism? Daltonism is a re

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd