Explain the bioavailability of folate, Biology

Assignment Help:

Explain the Bioavailability of Folate?

Bioavailability of folate from naturally occurring food sources is variable and frequently incomplete, as mentioned earlier in the food sources section. The bioavailability of natural folates is affected by the removal of the polyglutamate chain by the intestinal conjugase. This process is apparently not complete, thereby reducing the bioavailability of natural folates by as much as 25-5096. In contrast, synthetic folic acid appears to be highly bio available- 85% or greater. The low bioavailability and, more importantly, the poor chemical stability of the natural folates have a profound influence on the development of nutrient recommendations. This is particularly true if some of the dietary intake is as stable and bio available as the synthetic fonn, folic acid. Fortification of foods such as breakfast cereals and flour can add significant amounts of folic acid to the diet.

Since folic acid (synthetic) taken with food is 85% bio available but food folate is only about 50% bio available, folic acid taken with food is 85150 (i.e. 1.7) times more  available. Thus, if a mixture of synthetic folic acid plus food folate bas been fed, dietary folate equivalents (DFEs) are calculated as follows to determine the EAR:

yg of DFE provided = [mg of food folate + (1.7 x mg of synthetic folic acid)].

To be comparable to food folate, only half as much folic acid is needed if taken on an empty stomach, i.e. lpg of DFE: = lmg of food folate = 0.5 mg of folic acid taken on an empty stomach = 0.6 mg of folic acid with meals.

Alcohol interferes with the absorption of folate and increases excretion of folate by the kidney.


Related Discussions:- Explain the bioavailability of folate

Explain about the nutritional requirements, Explain about the Nutritional R...

Explain about the Nutritional Requirements? Nutritional requirements are defined as 'intake levels of nutrients that meet specified criteria of adequacy such as normal growth,

Saliva spreading - temperature relations in animals, Normal 0 f...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Explain the fluoride toxicity, Explain the Fluoride Toxicity? Fluoride ...

Explain the Fluoride Toxicity? Fluoride is a cumulative toxin. Ingestion of fluoride 1.0-1.5 mg/L for several years may produce dental fluorosis, i.e. browning and pitting of t

To study if bacteria grow better where it is warm or cold, To study if bact...

To study if bacteria grow better where it is warm or cold Again inoculate two sterile dishes. Label one 'warm'  and the other 'cold'. Place the 1st dish in a dark warm place an

Define the petrifilm (dry film) method, Define the Petrifilm (dry film) Met...

Define the Petrifilm (dry film) Method? An alternative method to the conventional SPC is a Petrifilm (dry film) method. It is a non-petri dish plating system where a layer of n

How can we determine the status of brain function, How can we determine the...

How can we determine the status of brain function Neuropsychological assessment is the clinical practise of using tests and other behavioural evaluation instruments to determin

Explain nutritional support management for radiation therapy, Explain Nutri...

Explain Nutritional Support Management for radiation therapy? For managing these patients on radiation therapy, the following measures can be under taken: 1. Administration

Excretion, Excretory organ for protozoa

Excretory organ for protozoa

Define anaerobic exercise or energy system, Define Anaerobic Exercise or En...

Define Anaerobic Exercise or Energy System? Thus, exercises which are done for short bursts of time lasting only for few seconds (less than 120 sec) use only anaerobic system o

Are the xylem and the phloem made of living cells, Are the xylem and the ph...

Are the xylem and the phloem made of living cells? The cells that constitute the xylem ducts are dead cells killed by lignin deposition. The cells of the phloem are living

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd