Explain the bioavailability of folate, Biology

Assignment Help:

Explain the Bioavailability of Folate?

Bioavailability of folate from naturally occurring food sources is variable and frequently incomplete, as mentioned earlier in the food sources section. The bioavailability of natural folates is affected by the removal of the polyglutamate chain by the intestinal conjugase. This process is apparently not complete, thereby reducing the bioavailability of natural folates by as much as 25-5096. In contrast, synthetic folic acid appears to be highly bio available- 85% or greater. The low bioavailability and, more importantly, the poor chemical stability of the natural folates have a profound influence on the development of nutrient recommendations. This is particularly true if some of the dietary intake is as stable and bio available as the synthetic fonn, folic acid. Fortification of foods such as breakfast cereals and flour can add significant amounts of folic acid to the diet.

Since folic acid (synthetic) taken with food is 85% bio available but food folate is only about 50% bio available, folic acid taken with food is 85150 (i.e. 1.7) times more  available. Thus, if a mixture of synthetic folic acid plus food folate bas been fed, dietary folate equivalents (DFEs) are calculated as follows to determine the EAR:

yg of DFE provided = [mg of food folate + (1.7 x mg of synthetic folic acid)].

To be comparable to food folate, only half as much folic acid is needed if taken on an empty stomach, i.e. lpg of DFE: = lmg of food folate = 0.5 mg of folic acid taken on an empty stomach = 0.6 mg of folic acid with meals.

Alcohol interferes with the absorption of folate and increases excretion of folate by the kidney.


Related Discussions:- Explain the bioavailability of folate

Define the food sources of thiamin, Define the Food Sources of Thiamin? ...

Define the Food Sources of Thiamin? Thiamin is present in many food products and depending on the amount of vitamin present, we have categorized the foods as rich, good or fair

What is the procedure of gas exchange in human body, What is the procedure ...

What is the procedure of Gas Exchange in human body? Exchange of oxygen with the blood is a specialized process. If oxygen were carried in solution in blood plasma (the liquid

Explain economic status of diet, Economic Status Economic Status  :  I...

Economic Status Economic Status  :  It is one of the important practical considerations to be kept in mind while  formulating  a diet prescription. During  an acute illness, a

Define clinical manifestations associated with cancer, Define Clinical Mani...

Define Clinical Manifestations and Nutritional Problems Associated with Cancer? In the previous section we learnt that cancer results in several changes in the metabolism of ca

Downers cow syndrome, D o w n e r s cow syndrome The Downer's co...

D o w n e r s cow syndrome The Downer's cow, otherwise known as creepers, is commonly a fatal condition of dairy animal associated with the unsuccessful treatment of cas

Zoology, anthropoda locomotion

anthropoda locomotion

What are the main bryophyte groups, Q. What are the main bryophyte groups? ...

Q. What are the main bryophyte groups? The major bryophyte groups are the mosses, the hornworts and the liverworts.

Examination of the prosthesis, Examination of the Prosthesis It is impo...

Examination of the Prosthesis It is important to examine the prosthesis thoroughly.  This involves assessing mobility, checking screws, evaluating attachments and porcelain res

Environment and health- impact of air and water pollution, Environment and ...

Environment and Health- Impact of Air and Water Pollution Environment includes a host of factors of which air and water are the two major components. Air pollution is caused b

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd