Diabetes mellitm

This anabolic hormone exerts its action on key glycolytic  enzymes  thus  leading  to the conversion of glucose  to  pyruvate as explained under the regulation of glycolysis. On the other hand, insulin suppresses the action of all key gluconeogenic enzymes. With respect to glycogen metabolism,  the excess glucose is converted  to glycogen by activating  glycogen synthase  thus leading  to glycogenesis  and inhibiting glycogenolysis. In this metabolic disease-diabetes mellitus, the lack of  insulin reverses these actions  and the antagonistic hormones  (like  glucagon, epinephrine, catecholamines, thyroxine  etc.)  by their concerted efforts  on various ~athwavs  brine:  about  the hyperglycemic condition.