Explain Specific Defence Mechanism

In the section on white blood cells, we learnt that whenever a germ or infection enters our body, the WBCs snap to attention and destroy the culprit. How does a white blood cell know what to attack and what to leave alone? Why doesn't a white blood cell attack every cell in the body? The answer to these questions lies in the discussion below.

The specific defence mechanism provides protection against specific foreign materials. The important characteristic is that its cells (lymphocytes) have an ability to recognize body's own cells and macro molecules (self) from those which are foreign invaders (non self ). It tolerates the 'self' but destroys the 'non self'. The lymphocytes bearing receptor is specific for self i.e. molecules already present in the body, are either made non-functional or destroyed by programmed cell-death known as apoptosis. The lymphocytes that react to non self i.e. foreign molecules are left to function in immune responses.

So, you realize that there is a system built into all of the cells in our body that marks the cells in our body as "self '. Anything that the immune system finds that does not have these markings (or that has the wrong markings) is definitely "not self" and is therefore a fair game. This system is called the Major Histocompatibility Complex (MHC).