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Prostaglandins
Prostaglandins belong to a subclass of lipids known as the eicosanoids because of their structural similarities to the C-20 polyunsaturated fatty acids, the eicosanoic acids. Prostaglandins are known to occur in almost all tissues in very small quantities and have important physiologic and pharmacologic activities. These are synthesized in vivo by cyclization of arachidonic acid, which is either derived from dietary linoleic acid or ingested as such, to form a cyclopentane ring. There are three fatty acids known as eicosanoic acids (characterized by the number of double bonds present in the structure), which by joining with the cyclopentane ring, gives rise to three groups of prostaglandins viz. PGI, PG2, PG3. These are listed in Table:-
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