Explain phosphofiuctokinase-i, Biology

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Phosphofiuctokinase-I

Phosphofiuctokinase-I  is activated by AMP and  inhibited by ATP and citrate. When ATP is utilized in energy requiring process, the concentration ofAMP  is highly increased. Thus a large increase in AMP acts as ametabolic amplifier of a small change in ATP. This mechanism allows the activity of phosphofructokinase-1  to be highly sensitive  to even small changes  in energy  status ofthe  cell and  to control the quantity  of carbohydrate undergoing  glycolysis prior  to its entry  into citric acid cycle. The increase in AMP also explains why glycolysis is increased during  hypoxia when ATP decreases.

 


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