Adverse Effects of voriconzole

Transient visual disturbances, including blurred vision, photophobia and altered perception of color or image, are common with voriconazole. Rash, photosensitivity, increased transaminase activity and hallucinations have also occurred. In patients with creatinine clearance <50 mL/min the drug should be given orally if possible, instead of intravenously, because the solubilizing agent (sulfobutylether- b-cyclodextrin), not voriconazole itself, can accumulate. Patients with mild to moderate hepatic cirrhosis should receive a normal loading dose of voriconazole, but half of the maintenance dose.