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1. DNA must be extensively folded in order to fit inside a nucleus that is less than 10 um in diameter.
a. Describe how DNA is folded into chromatin structures of increasing compaction and how chromosome are organised within the nucleus
b. using specific examples describe how chromatin structure, chromatin modifications and gene regulation are functionally linked
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Changes those are associated with programmed cell death, containing release of apoptotic bodies, blebbing, and nuclear fragmentation.
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