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Define the Blood coagulation - Function of Vitamin K?
The primary function of vitamin K in the body is in the maintenance of normal blood coagulation. The vitamin K-dependent coagulation proteins are synthesized in the liver and comprise Factor IT (prothrombin), Factor VII (proconvertin), Factor IX (Christmas factor) and Factor X (Stuart factor), which have a haemostatic role i.e. they are procoagulants that arrest and prevent bleeding.
Let us get to know how this mechanism works. Prothrombin is converted to its active form, thrombin, which in turn, is necessary for the formation of fibrin, a protein that is the basis for a blood clot, as shown in Figure. Vitamin K also acts as a cofactor for an enzyme in the liver which converts glutamic acid residues in a precursor process to gamma - carboxy glutamic acid. This reaction is necessary before prothrombin can function in blood coagulation.
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