Define role in growth and cellular differentiation, Biology

Assignment Help:

Define Role in growth and cellular Differentiation?

The growth and differentiation of epithelial cells throughout the body are especially affected by vitamin A deficiency.  In addition, goblet cell numbers we reduced in epithelial tissues and as a consequence, mucous secretions diminish. Cells lining protective tissue surfaces fail to regenerate and differentiate; hence they flatten and accumulate keratin.  Classical symptoms of xerosis (drying or non-wet ability) and desquamation of  dead surface cells as seen in ocular tissue (i.e. xerophthalmia) are the external  evidence of the changes also occurring to various degrees in internal epithelial  tissues. Current understanding of the mechanism of vitamin A action within cells outside the visual cycle is that cellular functions are mediated through specific nuclear receptors. Binding with specific isomers of retinoic acid (i.e.all Tran- and 9-cis-retinoic acid) activates these receptors. Activated receptors bind to DNA response elements located upstream of specific genes to regulate the level of expression of those genes. These retinoid-activated genes regulate the synthesis of a large number of proteins vital to maintaining normal physiologic functions. There may, however be other mechanisms of action that are as yet undiscovered.

 


Related Discussions:- Define role in growth and cellular differentiation

Nutrient budgets - nutrient cycles, Nutrient Budgets - Nutrient Cycles ...

Nutrient Budgets - Nutrient Cycles Nutrients are constantly being added and removed by natural and artificial processes. The measure of the input and outflow of nutrients thro

Describe how to prepare 200 ml of naoh, Describe how you would prepare 200 ...

Describe how you would prepare 200 ML of a 0.25 Msoluation of NaOH from a 3 M stock solution?

What is the fact of molecular biology, What is the fact of Molecular Biolog...

What is the fact of Molecular Biology on which DNA fingerprint is based? DNA fingerprint, the method of individual identification using DNA, is based on the fact that the DNA o

Respiration, abnormal lung volumes and capacities

abnormal lung volumes and capacities

Liver, how the gall bladder develops in a trnsplanted liver tissue ?

how the gall bladder develops in a trnsplanted liver tissue ?

Antibiotic resistance, Antibiotic resistance is the resistance conferred t...

Antibiotic resistance is the resistance conferred to the host the ability to survive a given antibiotic by the plasmids containing resistance genes. If such kind of plasmid is pre

Explain about bimodal diurnal pattern, Explain about bimodal diurnal patter...

Explain about bimodal diurnal pattern Animals that show a bimodal diurnal pattern have their activity controlled by two biological clocks -  one that controls the time of onset

What do you mean by zoological nomenclature, What do you mean by Zoological...

What do you mean by Zoological Nomenclature? This trust is housed in the British Museum, London and is responsible for some of the most important literature in Zoological Nomen

What proportion of children with down syndrome, What proportion of children...

What proportion of children with Down syndrome do you expect when women with down syndrome have children with men who have 46 chromosomes Justify your answer

Action of hormones, Action of Hormones We said earlier that hormones a...

Action of Hormones We said earlier that hormones are released into the blood stream or extracellular fluid and therefore, reach most of the cells of the body. However, they

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd