Define role in growth and cellular differentiation, Biology

Assignment Help:

Define Role in growth and cellular Differentiation?

The growth and differentiation of epithelial cells throughout the body are especially affected by vitamin A deficiency.  In addition, goblet cell numbers we reduced in epithelial tissues and as a consequence, mucous secretions diminish. Cells lining protective tissue surfaces fail to regenerate and differentiate; hence they flatten and accumulate keratin.  Classical symptoms of xerosis (drying or non-wet ability) and desquamation of  dead surface cells as seen in ocular tissue (i.e. xerophthalmia) are the external  evidence of the changes also occurring to various degrees in internal epithelial  tissues. Current understanding of the mechanism of vitamin A action within cells outside the visual cycle is that cellular functions are mediated through specific nuclear receptors. Binding with specific isomers of retinoic acid (i.e.all Tran- and 9-cis-retinoic acid) activates these receptors. Activated receptors bind to DNA response elements located upstream of specific genes to regulate the level of expression of those genes. These retinoid-activated genes regulate the synthesis of a large number of proteins vital to maintaining normal physiologic functions. There may, however be other mechanisms of action that are as yet undiscovered.

 


Related Discussions:- Define role in growth and cellular differentiation

Need for microbiological analysis of environment sample, Explain Need For M...

Explain Need For Microbiological Analysis of Environment Samples? Once the food is harvested, it passes through various operating steps before reaching the consumer. These step

Define investigative techniques in nutritional biochemistry, Define Investi...

Define Investigative Techniques in Nutritional Biochemistry? It is an important component of this manual as it focuses on providing an understanding of biochemical methods, tec

Evolutionary innovation presented by nematodes, Q. What is the major evolut...

Q. What is the major evolutionary innovation presented by nematodes? What is the benefits of that innovation? The major evolutionary innovation of nematodes is the complete dig

Explain about the shade drying, Explain about the Shade Drying? Shade d...

Explain about the Shade Drying? Shade drying is carried out for products which can lose their colour and/or turn brown if put in direct sunlight. Products that have naturally v

Types of radiography, Types of Radiography: Positron Emission Tomogra...

Types of Radiography: Positron Emission Tomography  (PET) Uses high-energy physics and computer techniques to  study  lung function; useful for quantitative measurement

What are biogeochemical cycles, What are biogeochemical cycles? Biogeoc...

What are biogeochemical cycles? Biogeochemical cycles are representations of the circulation and recycling of matter in nature. The major biogeochemical cycles studied in Ec

What are the roles of atp and nadph, Q. What are the roles of ATP and NADPH...

Q. What are the roles of ATP and NADPH in the chemical stage of photosynthesis? NADPH acts as reductant of carbon dioxide it delivers highly energetic hydrogen to precursor mol

Nursing assessment of thalassemia patient, Nursing Assessment  If you ...

Nursing Assessment  If you observe a child of thalassemia major you can identify the following clinical  manifestations:  Anaemia with haemoglobin level of 3 to 8 gm per ce

Tunnel subvalvar stenosis, Tunnel Subvalvar Stenosis :  This variety ...

Tunnel Subvalvar Stenosis :  This variety is less common and extends from sub aortic area for a variable length of 10-30 mms (tunnel stenosis). In the severe variety, the tun

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd