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Define Role in growth and cellular Differentiation?
The growth and differentiation of epithelial cells throughout the body are especially affected by vitamin A deficiency. In addition, goblet cell numbers we reduced in epithelial tissues and as a consequence, mucous secretions diminish. Cells lining protective tissue surfaces fail to regenerate and differentiate; hence they flatten and accumulate keratin. Classical symptoms of xerosis (drying or non-wet ability) and desquamation of dead surface cells as seen in ocular tissue (i.e. xerophthalmia) are the external evidence of the changes also occurring to various degrees in internal epithelial tissues. Current understanding of the mechanism of vitamin A action within cells outside the visual cycle is that cellular functions are mediated through specific nuclear receptors. Binding with specific isomers of retinoic acid (i.e.all Tran- and 9-cis-retinoic acid) activates these receptors. Activated receptors bind to DNA response elements located upstream of specific genes to regulate the level of expression of those genes. These retinoid-activated genes regulate the synthesis of a large number of proteins vital to maintaining normal physiologic functions. There may, however be other mechanisms of action that are as yet undiscovered.
Explain the DNA structure in details? Structure : Each DNA molecule is a double stranded polymer, consisting of perhaps thousands or millions of linked nucleotides. The two
Explain Procedure for Acid Fast Staining? Carry out the exercise using the steps enumerated herewith. 1. Label the clean, non-greasy slides and make smears of M. smegmatis,
Nudation - Processes in Succession The first step or requirement is the availability of the right kind of habitat, primary succession takes place in a bare area, that is, with
DIFFERENCE S BETWEEN STRIATED, NON-STRIATED AND CARDIAC MUSCLE FIBRES - Striated Non-striat
Define the Functional Properties of Proteins? a) Hydration properties (dependent on protein-water interactions), which include properties like swelling, adhesion, dispersibilit
What is the type of genetic inheritance of daltonism? Is daltonism more frequent in men or in women? What is the physiological explanation for the daltonism ? The Daltonism
Q. Which type of polarity do water-soluble and fat-soluble substances respectively have? Water-soluble substances are polar molecules that are they have electrically charged ar
Q. Vitamins and minerals requirement in diabetes? The recommendation of vitamins and minerals is the same as for general population. However, lower levels of magnesium are ass
Q. How different are the concepts of action potential, resting potential and excitation threshold concerning neurons? Action potential is the maximum positive voltage level ach
Fire Protection - Factors Affecting Occupational Health Fire protection and extinguishing devices require to be installed at proper places in the work place and proper notices
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