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Define Role in growth and cellular Differentiation?
The growth and differentiation of epithelial cells throughout the body are especially affected by vitamin A deficiency. In addition, goblet cell numbers we reduced in epithelial tissues and as a consequence, mucous secretions diminish. Cells lining protective tissue surfaces fail to regenerate and differentiate; hence they flatten and accumulate keratin. Classical symptoms of xerosis (drying or non-wet ability) and desquamation of dead surface cells as seen in ocular tissue (i.e. xerophthalmia) are the external evidence of the changes also occurring to various degrees in internal epithelial tissues. Current understanding of the mechanism of vitamin A action within cells outside the visual cycle is that cellular functions are mediated through specific nuclear receptors. Binding with specific isomers of retinoic acid (i.e.all Tran- and 9-cis-retinoic acid) activates these receptors. Activated receptors bind to DNA response elements located upstream of specific genes to regulate the level of expression of those genes. These retinoid-activated genes regulate the synthesis of a large number of proteins vital to maintaining normal physiologic functions. There may, however be other mechanisms of action that are as yet undiscovered.
What is the OBJECTIVES of evaluation of patient clinical examination ? After going through this unit, you should be able to: 1. Carried out the general physics-examination; 2.
Define the Clinical Manifestations of Underweight? Underweight may predispose to fatigue, lethargy and breathlessness. Iron-deficiency anaemia is usually seen because the diet
How many regulatory enzyme types known in metabolic pathways, explain in detail by giving examples.
what are structural adaptation of flatworm to it''s enviroment /
Explain the Criteria for Assessment of Vitamin Status? Vitamin E is assessed by determining the plasma lipid fraction levels. 0.8 mg of total tocopherol/g total plasma lipids i
Nuclear run-on is a technique used to estimate the relative rate of the transcription of a given gene, as opposed to steady-state level of the mRNA transcript (which is influenced
What is Modified Blalock-Taussig Shunt explain? This is usually done by interpositioning a PTFE (Goretex) graft of 3.5 or 4 mm in a neonate. It is better done by a left lateral
Injury to adrenal cortex is not likely to affect the secretion of which one of the following? 1. Aldosterone 2. Both Androstenedione and Dehydroepiandrosterone 3. Adrenali
Hydrogen ( h) has 1 electron; Carbon ( c) has 6 electrons, use the octet rule to determine which of the following is most stable. Note: some of these may have double bonds. A. O
Why is an S strain of bacteria able to cause disease in mammals but a R strain is not? The slippery capsule stops the cells of the defence system from capturing and destroying
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