Define physiological effects of scfa, Biology

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Define physiological effects of SCFA?

The physiological effects of SCFA's can be summarized as follows. They:

  • Lower the ph in the gastrointestinal tract, which in turn reduces the colonization of pathogenic bacteria (acid-sensitive). Lowering of ph also increases ionization of toxic compound, thereby reducing their absorption,
  • Stimulate colonic blood flow and motor activity,
  • Enhance water and electrolyte absorption,
  • Stimulate colonocyte proliferation,
  • Butyrate is a preferred substrate for colonocyte and contributes to energy needs of the colonic epithelial cell. Acetate and to a lesser extent propionate are absorbed into the system and contribute to energy needs of the host.
  • Butyrate enhances DNA stabilization and repair, induces apoptosis in potential cancer cells and thus promote a normal cell phenotype.

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