Cytoplasm plays the most important pathogenetic role, Biology

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The formation of surface blebs caused by ischemia reflects in part plasma membrane injury, but also a sign of cytoplasmic injury. Which filamentous component of the cytoplasm plays the most important pathogenetic role in the formation of these blebs?

peroxisomes

phospholipids

cytoskeleton

mitochondria

endoplasmic reticulum

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