Clotting mechanism, Biology

Assignment Help:

Clotting Mechanism

Four substances are necessary for coagulation of blood; prothrombin, thromboplastin, calcium and fibrinogen. Prothrombin gives rise to thrombin, an enzyme. Fibrinogen, prothrombin, and calcium are present in circulating blood. Thromboplastin (a lipid or fat-like compound containing phosphorus) is widely distributed throughout the tissues, the lung and brain being especially rich in this factor. It is absent or present in only small quantities in blood plasma. When blood is shed, thromboplastin is liberated from injured tissue and probably also from the leucocytes of the blood itself. The thromboplastin, acting upon the prothrombin in the presence of calcium in an ionised form, converts, it to active thrombin. Thrombin acts in turn upon the inactive fibrinogen, converting it into insoluble fibrin which is deposited as fine threads to form the framework of the clot. In simplest possible terms the chief factors are summarised in the following scheme:

 

248_Clotting Mechanism.png

Blood does not normally clot in the blood vessels because there is not sufficient free thromboplastin to convert the inactive prothrombin into the active thrombin.


Related Discussions:- Clotting mechanism

Illustrate pulmonary artery enlargement, Q. Illustrate Pulmonary Artery Enl...

Q. Illustrate Pulmonary Artery Enlargement? On the PA view, the pulmonary trunk is border forming for a short distance between the aortic knuckle and the left atrial appendage.

Fungi, what is primitive fungi?

what is primitive fungi?

Define measuring body composition- skin fold measurement, Define measuring ...

Define measuring body composition- Skin fold measurement? The clinical use, skin fold measurement can be taken with the help of calipers. The calipers are applied at constant p

Show the pre-diabetes conditions, Q. Show the Pre-Diabetes Conditions? ...

Q. Show the Pre-Diabetes Conditions? Pre-diabetes is a condition which may occur between normal and diabetes stages. It is important for you to know about this group of people,

Thermodynamics and cell shapes, Thermodynamics and Cell Shapes Why are...

Thermodynamics and Cell Shapes Why are protoplasts (cells devoid of cell wall) spherical? Why are most of the unicellular organisms (prokaryotes and eukaryotes) spherical? A s

Determine the implant placement, Implant placement The ideal siting and...

Implant placement The ideal siting and orientation of the implant is dictated by the restorative requirements, but this may have to be modified by the existing ridge morphology

Explain about the absorbed moisture - water found in food, Explain about th...

Explain about the Absorbed Moisture - water found in food? It is the moisture that has passed through cell walls and entered the cytoplasm of the cell. It is this form of water

What is an accommodation, What is an accommodation? Accommodation is th...

What is an accommodation? Accommodation is the ability of the eye to focus on an object situated at variable distances from the eye. Like a camera, even the eye requires to cha

What are the main cellular functions of potassium, What are the main cellul...

What are the main cellular functions of potassium? Besides being significant for the osmotic regulation and for the acid-base equilibrium (pH) potassium is basic for the excita

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd