Clinical features - infective endocarditis, Biology

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The clinical manifestations of IE result from

the local destructive effects of intracardiac infection;
the embolization of bland or septic fragments of vegetations to distant sites, resulting in infarction or infection;
the hematogenous seeding of remote sites during continuous bacteremia; and
an antibody response to the infecting organism with subsequent tissue injury due to deposition preformed immune complexes or antibody complement interaction with antigens deposited in tissues.

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