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• Cancer cells do not respond normally to the body's control mechanism.
o They divide excessively and invade other tissues.o If left unchecked, they can kill the organism.
• Cancer cells do not exhibit contact inhibition
o If cultured, they continue to grow on top of each other when the total area of the petri dish has been covered o They may produce required external growth factor (or override factors) themselves or possess abnormal signal transduction sequences which falsely convey growth signals thereby bypassing normal growth checks.
• Cancer cells exhibit irregular growth sequences
o If growth of cancer cells does cease, it does so at random points of the cell cycle o Cancer cells can go on dividing indefinitely if they are given a continual supply of nutrients o Normal mammalian cells growing in culture only divide 20-50 times before they stop dividing.
As bone looses width, height, volume, the attached gingiva gradually decreases and is prone to abrasions caused by the overlying prosthesis. In addition high muscle attachments and
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