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PP, a 52-year-old woman with restless leg syndrome (RLS), is experiencing worsening symptoms despite the use of pramipexole 0.25 mg Q12H for over a year. She presents to the clinic complaining that her RLS symptoms are beginning earlier in the day and are more intense than in the past. Based on her complaints, PM's health care provider believes she is experiencing mild dopaminergic augmentation (worsening symptoms with continued use of dopaminergic agents). PM is not taking any other prescription or OTC medications, limits her alcohol and caffeine intake, exercises 3 times a week, and typically gets at least 8 hours of sleep a night. Her iron panel results (serum iron, ferritin, and total iron-binding capacity) are all within normal limits.
Would you change the medication? If yes, why, which medication(s) would you change it to, and include the dose? Any labs you need to monitor?
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