Why is there a hyperdynamic circulation in cirrhosis

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Assignment:

Medications. Propranolol (Inderal) and primidone (Mysoline) are most effective in reducing tremors. Propranolol is a beta blocker, also used to treat high blood pressure and performance anxiety. Its side effects are mild to moderate and include slow heartbeat, fatigue, and shortness of breath. (People with asthma should not take propranolol.) Primidone is an antiseizure medication with mild to moderate side effects that include drowsiness, difficulty concentrating, nausea, and dizziness. Both of these drugs can reduce tremors by as much as 50%.

1. Hepatitis C (HCV): if results from the polymerase chain reaction (PCR) examination are inconclusive, what does this mean? Should further investigations be undertaken and, if so, will there be a risk of chronicity?

2. In a patient with hepatitis C and autoimmune hepatitis, can corticosteroids be prescribed for the autoimmune hepatitis?

3. We were told that the more vascular a structure is, the more antigen (HLA/blood groups) matching is needed for transplantation, e.g. cornea transplant needs no matching. However, the liver is a very vascular organ; I don't know why liver transplantation needs blood group matching only but renal transplantation needs much more HLA matching.

4. About steatohepatitis: please give me more information about the occurrence of cirrhosis in such patients (non-alcoholic) and is there any role and indication for lipotropic agents and hypocholesterolaemic drugs?

5. I am working on non-alcoholic fatty liver disease (NAFLD) but I did not find anything regarding it. Can you tell me about its relationship with lipids?

6. Is NASH a valid term or not and what manifestation has it?

7. Is terlipressin better in controlling variceal bleeding than somatostatin?

8. Why is there a hyperdynamic circulation in cirrhosis?

9. Why is there an increased level of immunoglobulin G (IgG) in patients with cirrhosis?

10. Cirrhosis of liver is reversible according to your book. What is the progress and when will we be able to counteract the 'tissue inhibitors of metalloproteinases' (TIMPs) and thus save the lives of our patients?

Reference no: EM133856963

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