What is pharmacokinetics between sodium valproate

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Reference no: EM133864031

Assignment:

Ensure that the answers given are all correct and detailed General practitioners are sometimes involved in the registration of occupational diseases and could also register cases of occupational diseases that are not picked up by occupational physicians and other OSH professionals involved. However, some information would be needed to make such information useful for workplace purposes, for instance on the work history of the person in question. It could be supplemented by information from job-exposure matrices as proposed by some experts in the stakeholder workshop.

The Finnish institute for occupational health FIOH has developed the FINJEM, the Finnish Job Exposure Matrix. Even when only a job title is known, the exposure of a worker can be estimated based on the exposures measured in large groups of workers with similar job titles. Exposures that are relevant for biological hazards in the FINJEM database are those to organic dusts (such as animal, flour, plant, softwood and hardwood dust) and to microbiological agents (mould spores and gram-negative bacteria of non-human origin). Other job-exposure matrices could be built on this model.

1. I'd like to know the possibility of giving these drugs in epileptics: vincamine (Oxicebral), cinnarizine, piribedil (Trivastal) and pentoxyphylline (Trental). I'd like to know if they are contraindicated.

2. If an epileptic patient, treated with oxcarbazepine, develops a rash, should this drug be withdrawn or the dosage decreased and then increased gradually again?

3. Does a patient with refractory epilepsy benefit from acetazolamide?

4. What anti-epileptic drug is recommended for a child with epilepsy and co-morbid attention deficit hyperactivity disorder (ADHD)? Can Ritalin safely be used for treatment?

5. What is the difference in efficacy and pharmacokinetics between sodium valproate and valproic acid?

6. Is it safe to give valproic acid to infants below 12 months of age?

7. How many times must the liver transaminases (SGOT and SGPT) rise to justify a discontinuation of valproic acid therapy in children? Which of these enzymes is more sensitive and reliable in this situation?

8. 1. Does valproic acid block the photosensitivity phenomenon in reflex epilepsy?

2. Can a patient with this photosensitivity be safely exposed to computer games or other photic stimuli when receiving valproic acid treatment?

3. Does the photosensitivity phenomenon occur in partial seizures?

9. 1. Can an epileptic fit be induced in idiopathic and symptomatic focal epilepsy syndromes by flickering lights?

2. Is valproate effective against the photosensitive phenomenon (seizure induction by flickering light)?

10. How much time should one give before a loading dose of phenytoin is judged to be ineffective in controlling seizures and an alternative should be instituted?

Reference no: EM133864031

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