Reference no: EM133857357

Assignment:

Please help with the following Eggs are one of nature's most nutritious and economical foods, but fresh eggs must be handled carefully. Even eggs with clean, uncracked shells may occasionally contain Salmonella. To prevent food poisoning, keep eggs refrigerated, cook eggs until yolks are firm, and cook foods containing eggs thoroughly.

1. What else could we use instead of propranolol in thyrotoxicosis with bronchial asthma?

2. At what dose, and for how long, would steroid therapy give rise to secondary adrenal insufficiency? For adrenal insufficiency due to longterm steroid use, when should we start to give a cortisone supplement? How should we monitor these patients?

3. What dose of Synacthen is equivalent to adrenocorticotrophic hormone (ACTH)?

4. I want to know the mechanism that causes anaemia in Addison's disease. I am unable to find the real cause.

5. What causes hypercalcaemia in Addison's disease?

6. In the diagnosis of Cushing's disease using the high-dose dexamethasone suppression test, how can the exogenous steroid suppress adrenocorticotrophic hormone (ACTH) when the grossly elevated serum cortisol levels fail to do so?

7. Does alternate-day therapy with steroids decrease their efficacy compared with daily therapy?

8. Regarding the renin-angiotensin-aldosterone axis, it states that dietary sodium excess suppresses renin secretion. Then why are we asking hypertensives to restrict sodium intake? Also if we are using angiotensinconverting enzyme (ACE) inhibitors, the plasma renin activity increases due to loss of feedback inhibition. Wouldn't that be counterproductive?

9. How does a phaeochromocytoma give rise to Raynaud's phenomenon?

10. How well do symptoms of hypercalcaemia correlate with serum calcium levels. Can I ignore an asymptomatic patient with a serum calcium of 3.7 mmol/L but have to give treatment to a symptomatic patient who has a serum calcium of 3.3 mmol/L?