Treated for depression with specific medication

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A patient is being treated for depression with a specific medication. The pharmacokinetic profile of this medication reveals a dissociation constant (Kd) of 344 pg/mL and an effective dose for 50% of the population (ED50) of 200 pg/mL. What can be inferred from these pharmacokinetic parameters? The drug requires full receptor saturation to be effective, as indicated by the Kd and ED50 values. The medication is likely to cause severe side effects due to high potency. An ED50 lower than Kd suggests the drug is ineffective. The drug's high Kd value indicates it has a very high binding affinity. The presence of spare receptors can be inferred from these values.

Reference no: EM133680691

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