Series of steps by which ingestion of mothballs

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Reference no: EM133934620

Stage 1: JIMMY HARRIS ©Allen, D. E. 1998. Thinking Toward Solutions. Orlando, FL: Harcourt Brace and Co. Jimmy Harris, an eight-year-old African American boy, is brought into the emergency room of Christiana Hospital by his parents. He appears pale and jaundiced and has been passing dark red urine. His mother reports that Jimmy's friends confessed that they had dared him to swallow some mothballs, but hadn't stuck around long enough to know just how many he may have swallowed (or if he had swallowed any at all). The results of blood tests and urinalysis show elevated levels of methemoglobin in the blood, presence of "Heinz bodies" in some of Jimmy's red blood cells (and of pieces missing from the borders of many others), and hemoglobinemia and hemoglobinuria. Subsequent assays of red cell hemolysates reveal a 95% reduction in activity of the enzyme glucose-6- phosphate dehydrogenase (G6PD). Dr. Mancado, the admitting physician, arrives at a preliminary diagnosis.

Questions to ponder:

1. Why do you think the lab has reported Jimmy's enzyme assay results as reduction in activity?

2. What would be your diagnosis of Jimmy's condition?

3. Outline the series of steps by which ingestion of mothballs could have led to Jimmy's symptoms.

4. Would individuals with close to 100% of normal G6PD activity respond the same way as Jimmy did to ingestion of mothballs?

Reference no: EM133934620

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